node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP1 | LOX | ENSBTAP00000001218 | ENSBTAP00000068980 | Metalloendopeptidase. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.848 |
BMP1 | LOXL1 | ENSBTAP00000001218 | ENSBTAP00000011978 | Metalloendopeptidase. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.744 |
BMP1 | LOXL3 | ENSBTAP00000001218 | ENSBTAP00000024724 | Metalloendopeptidase. | Lysyl oxidase like 3. | 0.714 |
BMP1 | LOXL4 | ENSBTAP00000001218 | ENSBTAP00000027838 | Metalloendopeptidase. | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. | 0.672 |
CHCHD1 | LOXL4 | ENSBTAP00000016785 | ENSBTAP00000027838 | Coiled-coil-helix-coiled-coil-helix domain containing 1. | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. | 0.576 |
ELN | FBLN5 | ENSBTAP00000069595 | ENSBTAP00000063953 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | 0.964 |
ELN | LOX | ENSBTAP00000069595 | ENSBTAP00000068980 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.968 |
ELN | LOXL1 | ENSBTAP00000069595 | ENSBTAP00000011978 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.925 |
ELN | LOXL3 | ENSBTAP00000069595 | ENSBTAP00000024724 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | Lysyl oxidase like 3. | 0.775 |
ELN | LOXL4 | ENSBTAP00000069595 | ENSBTAP00000027838 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. | 0.811 |
FBLN5 | ELN | ENSBTAP00000063953 | ENSBTAP00000069595 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | 0.964 |
FBLN5 | LOX | ENSBTAP00000063953 | ENSBTAP00000068980 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.915 |
FBLN5 | LOXL1 | ENSBTAP00000063953 | ENSBTAP00000011978 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.927 |
FBLN5 | LOXL3 | ENSBTAP00000063953 | ENSBTAP00000024724 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | Lysyl oxidase like 3. | 0.643 |
FBLN5 | LOXL4 | ENSBTAP00000063953 | ENSBTAP00000027838 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. | 0.606 |
HOXC9 | ING5 | ENSBTAP00000007361 | ENSBTAP00000012025 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. | Inhibitor of growth family member 5. | 0.502 |
HOXC9 | LOXL4 | ENSBTAP00000007361 | ENSBTAP00000027838 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. | 0.585 |
ING5 | HOXC9 | ENSBTAP00000012025 | ENSBTAP00000007361 | Inhibitor of growth family member 5. | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. | 0.502 |
ING5 | LOXL4 | ENSBTAP00000012025 | ENSBTAP00000027838 | Inhibitor of growth family member 5. | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. | 0.557 |
LOX | BMP1 | ENSBTAP00000068980 | ENSBTAP00000001218 | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | Metalloendopeptidase. | 0.848 |