STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALX3ALX homeobox 3. (343 aa)    
Predicted Functional Partners:
GGT7
Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates.
      
 0.586
LHX4
LIM homeobox 4.
   
 
0.566
LHX3
LIM homeodomain 3 protein b isoform.
   
 
0.566
SPECC1L
Calponin-homology (CH) domain-containing protein.
      
 0.549
ZIC5
Zic family member 5.
    
 
 0.544
CDK14
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 
 0.542
LDB2
LIM domain binding 2.
    
   0.522
LDB1
LIM domain binding 1.
    
   0.522
ASIP
Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
      
 0.512
SMG6
SMG6 nonsense mediated mRNA decay factor.
      
 0.504
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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