node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCZ1 | ENSBTAP00000062766 | ENSBTAP00000004259 | ENSBTAP00000062766 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Uncharacterized protein. | 0.414 |
CCZ1 | TGFBRAP1 | ENSBTAP00000004259 | ENSBTAP00000028967 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity); Belongs to the TRAP1 family. | 0.807 |
CCZ1 | VPS11 | ENSBTAP00000004259 | ENSBTAP00000007042 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.986 |
CCZ1 | VPS16 | ENSBTAP00000004259 | ENSBTAP00000001744 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] | 0.982 |
CCZ1 | VPS18 | ENSBTAP00000004259 | ENSBTAP00000015368 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | VPS18 core subunit of CORVET and HOPS complexes. | 0.982 |
CCZ1 | VPS33A | ENSBTAP00000004259 | ENSBTAP00000005508 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. | 0.916 |
CCZ1 | VPS33B | ENSBTAP00000004259 | ENSBTAP00000000029 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesi [...] | 0.882 |
CCZ1 | VPS39 | ENSBTAP00000004259 | ENSBTAP00000006949 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | VPS39 subunit of HOPS complex. | 0.986 |
CCZ1 | VPS41 | ENSBTAP00000004259 | ENSBTAP00000009615 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.977 |
CCZ1 | VPS8 | ENSBTAP00000004259 | ENSBTAP00000053312 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | VPS8 subunit of CORVET complex. | 0.813 |
ENSBTAP00000062766 | CCZ1 | ENSBTAP00000062766 | ENSBTAP00000004259 | Uncharacterized protein. | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.414 |
ENSBTAP00000062766 | TGFBRAP1 | ENSBTAP00000062766 | ENSBTAP00000028967 | Uncharacterized protein. | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity); Belongs to the TRAP1 family. | 0.848 |
ENSBTAP00000062766 | VPS11 | ENSBTAP00000062766 | ENSBTAP00000007042 | Uncharacterized protein. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.915 |
ENSBTAP00000062766 | VPS16 | ENSBTAP00000062766 | ENSBTAP00000001744 | Uncharacterized protein. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] | 0.920 |
ENSBTAP00000062766 | VPS18 | ENSBTAP00000062766 | ENSBTAP00000015368 | Uncharacterized protein. | VPS18 core subunit of CORVET and HOPS complexes. | 0.917 |
ENSBTAP00000062766 | VPS33A | ENSBTAP00000062766 | ENSBTAP00000005508 | Uncharacterized protein. | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. | 0.884 |
ENSBTAP00000062766 | VPS33B | ENSBTAP00000062766 | ENSBTAP00000000029 | Uncharacterized protein. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesi [...] | 0.884 |
ENSBTAP00000062766 | VPS39 | ENSBTAP00000062766 | ENSBTAP00000006949 | Uncharacterized protein. | VPS39 subunit of HOPS complex. | 0.749 |
ENSBTAP00000062766 | VPS41 | ENSBTAP00000062766 | ENSBTAP00000009615 | Uncharacterized protein. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.466 |
ENSBTAP00000062766 | VPS8 | ENSBTAP00000062766 | ENSBTAP00000053312 | Uncharacterized protein. | VPS8 subunit of CORVET complex. | 0.900 |