node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTC | EGFR | ENSBTAP00000005549 | ENSBTAP00000070620 | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | Receptor protein-tyrosine kinase. | 0.996 |
BTC | ERBB4 | ENSBTAP00000005549 | ENSBTAP00000071940 | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | Receptor protein-tyrosine kinase. | 0.995 |
BTC | EREG | ENSBTAP00000005549 | ENSBTAP00000013571 | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | Epiregulin. | 0.791 |
BTC | HBEGF | ENSBTAP00000005549 | ENSBTAP00000029015 | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | Heparin binding EGF like growth factor. | 0.943 |
EGFR | BTC | ENSBTAP00000070620 | ENSBTAP00000005549 | Receptor protein-tyrosine kinase. | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | 0.996 |
EGFR | ERBB4 | ENSBTAP00000070620 | ENSBTAP00000071940 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.859 |
EGFR | EREG | ENSBTAP00000070620 | ENSBTAP00000013571 | Receptor protein-tyrosine kinase. | Epiregulin. | 0.999 |
EGFR | GPC1 | ENSBTAP00000070620 | ENSBTAP00000060932 | Receptor protein-tyrosine kinase. | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.489 |
EGFR | HBEGF | ENSBTAP00000070620 | ENSBTAP00000029015 | Receptor protein-tyrosine kinase. | Heparin binding EGF like growth factor. | 0.999 |
EGFR | MMP14 | ENSBTAP00000070620 | ENSBTAP00000019744 | Receptor protein-tyrosine kinase. | Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...] | 0.620 |
EGFR | MMP2 | ENSBTAP00000070620 | ENSBTAP00000025657 | Receptor protein-tyrosine kinase. | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] | 0.667 |
EGFR | MMP9 | ENSBTAP00000070620 | ENSBTAP00000027556 | Receptor protein-tyrosine kinase. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). Belongs to the peptidase M10A family. | 0.848 |
ERBB4 | BTC | ENSBTAP00000071940 | ENSBTAP00000005549 | Receptor protein-tyrosine kinase. | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | 0.995 |
ERBB4 | EGFR | ENSBTAP00000071940 | ENSBTAP00000070620 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.859 |
ERBB4 | EREG | ENSBTAP00000071940 | ENSBTAP00000013571 | Receptor protein-tyrosine kinase. | Epiregulin. | 0.998 |
ERBB4 | HBEGF | ENSBTAP00000071940 | ENSBTAP00000029015 | Receptor protein-tyrosine kinase. | Heparin binding EGF like growth factor. | 0.997 |
EREG | BTC | ENSBTAP00000013571 | ENSBTAP00000005549 | Epiregulin. | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). | 0.791 |
EREG | EGFR | ENSBTAP00000013571 | ENSBTAP00000070620 | Epiregulin. | Receptor protein-tyrosine kinase. | 0.999 |
EREG | ERBB4 | ENSBTAP00000013571 | ENSBTAP00000071940 | Epiregulin. | Receptor protein-tyrosine kinase. | 0.998 |
EREG | HBEGF | ENSBTAP00000013571 | ENSBTAP00000029015 | Epiregulin. | Heparin binding EGF like growth factor. | 0.958 |