node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASH2L | CXXC1 | ENSBTAP00000001294 | ENSBTAP00000029172 | ASH2 like, histone lysine methyltransferase complex subunit. | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | 0.996 |
ASH2L | DPY30 | ENSBTAP00000001294 | ENSBTAP00000012183 | ASH2 like, histone lysine methyltransferase complex subunit. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.999 |
ASH2L | EHMT2 | ENSBTAP00000001294 | ENSBTAP00000007456 | ASH2 like, histone lysine methyltransferase complex subunit. | Euchromatic histone lysine methyltransferase 2. | 0.571 |
ASH2L | RBBP5 | ENSBTAP00000001294 | ENSBTAP00000021204 | ASH2 like, histone lysine methyltransferase complex subunit. | RB binding protein 5, histone lysine methyltransferase complex subunit. | 0.999 |
ASH2L | SETD1A | ENSBTAP00000001294 | ENSBTAP00000068889 | ASH2 like, histone lysine methyltransferase complex subunit. | SET domain containing 1A, histone lysine methyltransferase. | 0.964 |
ASH2L | SETD1B | ENSBTAP00000001294 | ENSBTAP00000022553 | ASH2 like, histone lysine methyltransferase complex subunit. | SET domain containing 1B, histone lysine methyltransferase. | 0.979 |
ASH2L | WDR5 | ENSBTAP00000001294 | ENSBTAP00000061141 | ASH2 like, histone lysine methyltransferase complex subunit. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.999 |
ASH2L | WDR5B | ENSBTAP00000001294 | ENSBTAP00000061985 | ASH2 like, histone lysine methyltransferase complex subunit. | WD repeat domain 5B. | 0.975 |
ASH2L | WDR82 | ENSBTAP00000001294 | ENSBTAP00000003855 | ASH2 like, histone lysine methyltransferase complex subunit. | WDR82P1 protein. | 0.985 |
CXXC1 | ASH2L | ENSBTAP00000029172 | ENSBTAP00000001294 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | ASH2 like, histone lysine methyltransferase complex subunit. | 0.996 |
CXXC1 | DPY30 | ENSBTAP00000029172 | ENSBTAP00000012183 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.975 |
CXXC1 | EHMT2 | ENSBTAP00000029172 | ENSBTAP00000007456 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | Euchromatic histone lysine methyltransferase 2. | 0.782 |
CXXC1 | PIH1D1 | ENSBTAP00000029172 | ENSBTAP00000021978 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity); Belongs to the PIH1 family. | 0.844 |
CXXC1 | RBBP5 | ENSBTAP00000029172 | ENSBTAP00000021204 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | RB binding protein 5, histone lysine methyltransferase complex subunit. | 0.992 |
CXXC1 | SETD1A | ENSBTAP00000029172 | ENSBTAP00000068889 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | SET domain containing 1A, histone lysine methyltransferase. | 0.969 |
CXXC1 | SETD1B | ENSBTAP00000029172 | ENSBTAP00000022553 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | SET domain containing 1B, histone lysine methyltransferase. | 0.979 |
CXXC1 | WDR5 | ENSBTAP00000029172 | ENSBTAP00000061141 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.964 |
CXXC1 | WDR5B | ENSBTAP00000029172 | ENSBTAP00000061985 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | WD repeat domain 5B. | 0.829 |
CXXC1 | WDR82 | ENSBTAP00000029172 | ENSBTAP00000003855 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. | WDR82P1 protein. | 0.991 |
DPY30 | ASH2L | ENSBTAP00000012183 | ENSBTAP00000001294 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | ASH2 like, histone lysine methyltransferase complex subunit. | 0.999 |