STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM174BMembrane protein FAM174B; Essential for Golgi structural integrity. Belongs to the FAM174 family. (159 aa)    
Predicted Functional Partners:
LYSMD4
LysM domain containing 4.
      
 0.923
LYSMD3
LysM domain containing 3.
      
 0.666
ST8SIA2
Uncharacterized protein; Belongs to the glycosyltransferase 29 family.
      
 0.646
MFSD12
Major facilitator superfamily domain containing 12.
      
 0.613
RGMA
Repulsive guidance molecule BMP co-receptor a.
      
 0.611
IQCA1
IQ motif containing with AAA domain 1.
      
 0.576
TBC1D16
TBC1 domain family member 16.
      
 0.574
CRYGN
Crystallin gamma N; Belongs to the beta/gamma-crystallin family.
      
 0.560
SULT2B1
Sulfotransferase; Belongs to the sulfotransferase 1 family.
      
 0.542
THAP1
THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
      
 0.536
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.