node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASB10 | CUL5 | ENSBTAP00000033313 | ENSBTAP00000060422 | Ankyrin repeat and SOCS box containing 10. | Cullin 5; Belongs to the cullin family. | 0.477 |
ASB10 | ELOC | ENSBTAP00000033313 | ENSBTAP00000065112 | Ankyrin repeat and SOCS box containing 10. | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | 0.452 |
ASB10 | SPSB1 | ENSBTAP00000033313 | ENSBTAP00000068833 | Ankyrin repeat and SOCS box containing 10. | SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to [...] | 0.638 |
ASB10 | SPSB3 | ENSBTAP00000033313 | ENSBTAP00000022024 | Ankyrin repeat and SOCS box containing 10. | SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the SPSB family. | 0.400 |
ASB10 | UBE2F | ENSBTAP00000033313 | ENSBTAP00000036864 | Ankyrin repeat and SOCS box containing 10. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.517 |
ASB18 | SPSB1 | ENSBTAP00000002623 | ENSBTAP00000068833 | Ankyrin repeat and SOCS box containing 18. | SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to [...] | 0.512 |
CUL5 | ASB10 | ENSBTAP00000060422 | ENSBTAP00000033313 | Cullin 5; Belongs to the cullin family. | Ankyrin repeat and SOCS box containing 10. | 0.477 |
CUL5 | ELOC | ENSBTAP00000060422 | ENSBTAP00000065112 | Cullin 5; Belongs to the cullin family. | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | 0.999 |
CUL5 | ENSBTAP00000063090 | ENSBTAP00000060422 | ENSBTAP00000063090 | Cullin 5; Belongs to the cullin family. | Skp1_POZ domain-containing protein. | 0.782 |
CUL5 | ENSBTAP00000065609 | ENSBTAP00000060422 | ENSBTAP00000065609 | Cullin 5; Belongs to the cullin family. | Skp1_POZ domain-containing protein. | 0.782 |
CUL5 | SPSB1 | ENSBTAP00000060422 | ENSBTAP00000068833 | Cullin 5; Belongs to the cullin family. | SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to [...] | 0.674 |
CUL5 | SPSB3 | ENSBTAP00000060422 | ENSBTAP00000022024 | Cullin 5; Belongs to the cullin family. | SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the SPSB family. | 0.842 |
CUL5 | UBE2F | ENSBTAP00000060422 | ENSBTAP00000036864 | Cullin 5; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.929 |
ELOC | ASB10 | ENSBTAP00000065112 | ENSBTAP00000033313 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Ankyrin repeat and SOCS box containing 10. | 0.452 |
ELOC | CUL5 | ENSBTAP00000065112 | ENSBTAP00000060422 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Cullin 5; Belongs to the cullin family. | 0.999 |
ELOC | SPSB1 | ENSBTAP00000065112 | ENSBTAP00000068833 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to [...] | 0.740 |
ELOC | SPSB3 | ENSBTAP00000065112 | ENSBTAP00000022024 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the SPSB family. | 0.814 |
ELOC | UBE2F | ENSBTAP00000065112 | ENSBTAP00000036864 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.773 |
ENSBTAP00000063090 | CUL5 | ENSBTAP00000063090 | ENSBTAP00000060422 | Skp1_POZ domain-containing protein. | Cullin 5; Belongs to the cullin family. | 0.782 |
ENSBTAP00000063090 | ENSBTAP00000065609 | ENSBTAP00000063090 | ENSBTAP00000065609 | Skp1_POZ domain-containing protein. | Skp1_POZ domain-containing protein. | 0.563 |