node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESRRA | ESRRB | ENSBTAP00000036275 | ENSBTAP00000068235 | Estrogen related receptor alpha. | Estrogen related receptor beta. | 0.662 |
ESRRA | ESRRG | ENSBTAP00000036275 | ENSBTAP00000063061 | Estrogen related receptor alpha. | Estrogen related receptor gamma. | 0.622 |
ESRRA | MED1 | ENSBTAP00000036275 | ENSBTAP00000053186 | Estrogen related receptor alpha. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.619 |
ESRRA | NCOR1 | ENSBTAP00000036275 | ENSBTAP00000053758 | Estrogen related receptor alpha. | Nuclear receptor corepressor 1. | 0.848 |
ESRRA | NCOR2 | ENSBTAP00000036275 | ENSBTAP00000060821 | Estrogen related receptor alpha. | Nuclear receptor corepressor 2. | 0.654 |
ESRRA | NRF1 | ENSBTAP00000036275 | ENSBTAP00000060644 | Estrogen related receptor alpha. | Nuclear respiratory factor 1. | 0.682 |
ESRRA | NRIP1 | ENSBTAP00000036275 | ENSBTAP00000054302 | Estrogen related receptor alpha. | Nuclear receptor interacting protein 1. | 0.667 |
ESRRA | PPARGC1A | ENSBTAP00000036275 | ENSBTAP00000022636 | Estrogen related receptor alpha. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.992 |
ESRRA | PPARGC1B | ENSBTAP00000036275 | ENSBTAP00000068774 | Estrogen related receptor alpha. | PPARG coactivator 1 beta. | 0.765 |
ESRRA | TFAM | ENSBTAP00000036275 | ENSBTAP00000052192 | Estrogen related receptor alpha. | Transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymeras [...] | 0.698 |
ESRRB | ESRRA | ENSBTAP00000068235 | ENSBTAP00000036275 | Estrogen related receptor beta. | Estrogen related receptor alpha. | 0.662 |
ESRRB | ESRRG | ENSBTAP00000068235 | ENSBTAP00000063061 | Estrogen related receptor beta. | Estrogen related receptor gamma. | 0.428 |
ESRRB | MED1 | ENSBTAP00000068235 | ENSBTAP00000053186 | Estrogen related receptor beta. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.554 |
ESRRB | NCOR1 | ENSBTAP00000068235 | ENSBTAP00000053758 | Estrogen related receptor beta. | Nuclear receptor corepressor 1. | 0.692 |
ESRRB | NCOR2 | ENSBTAP00000068235 | ENSBTAP00000060821 | Estrogen related receptor beta. | Nuclear receptor corepressor 2. | 0.759 |
ESRRB | NRIP1 | ENSBTAP00000068235 | ENSBTAP00000054302 | Estrogen related receptor beta. | Nuclear receptor interacting protein 1. | 0.628 |
ESRRB | PPARGC1A | ENSBTAP00000068235 | ENSBTAP00000022636 | Estrogen related receptor beta. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.653 |
ESRRG | ESRRA | ENSBTAP00000063061 | ENSBTAP00000036275 | Estrogen related receptor gamma. | Estrogen related receptor alpha. | 0.622 |
ESRRG | ESRRB | ENSBTAP00000063061 | ENSBTAP00000068235 | Estrogen related receptor gamma. | Estrogen related receptor beta. | 0.428 |
ESRRG | MED1 | ENSBTAP00000063061 | ENSBTAP00000053186 | Estrogen related receptor gamma. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.554 |