Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but at higher resolution
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL5 | DCUN1D2 | ENSBTAP00000060422 | ENSBTAP00000024848 | Cullin 5; Belongs to the cullin family. | DCN1-like protein. | 0.514 |
CUL5 | NAE1 | ENSBTAP00000060422 | ENSBTAP00000013367 | Cullin 5; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.821 |
CUL5 | NEDD8 | ENSBTAP00000060422 | ENSBTAP00000003514 | Cullin 5; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.980 |
CUL5 | RBX1 | ENSBTAP00000060422 | ENSBTAP00000069463 | Cullin 5; Belongs to the cullin family. | RING-type domain-containing protein. | 0.999 |
CUL5 | RNF7 | ENSBTAP00000060422 | ENSBTAP00000002831 | Cullin 5; Belongs to the cullin family. | Ring finger protein 7. | 0.999 |
CUL5 | UBA1 | ENSBTAP00000060422 | ENSBTAP00000057326 | Cullin 5; Belongs to the cullin family. | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | 0.467 |
CUL5 | UBA3 | ENSBTAP00000060422 | ENSBTAP00000071509 | Cullin 5; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.900 |
CUL5 | UBE2F | ENSBTAP00000060422 | ENSBTAP00000036864 | Cullin 5; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.929 |
DCUN1D2 | CUL5 | ENSBTAP00000024848 | ENSBTAP00000060422 | DCN1-like protein. | Cullin 5; Belongs to the cullin family. | 0.514 |
DCUN1D2 | DCUN1D3 | ENSBTAP00000024848 | ENSBTAP00000043119 | DCN1-like protein. | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. | 0.466 |
DCUN1D2 | DCUN1D5 | ENSBTAP00000024848 | ENSBTAP00000004020 | DCN1-like protein. | DCN1-like protein 5. | 0.555 |
DCUN1D2 | NAE1 | ENSBTAP00000024848 | ENSBTAP00000013367 | DCN1-like protein. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.606 |
DCUN1D2 | NEDD8 | ENSBTAP00000024848 | ENSBTAP00000003514 | DCN1-like protein. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.849 |
DCUN1D2 | RBX1 | ENSBTAP00000024848 | ENSBTAP00000069463 | DCN1-like protein. | RING-type domain-containing protein. | 0.650 |
DCUN1D2 | RNF7 | ENSBTAP00000024848 | ENSBTAP00000002831 | DCN1-like protein. | Ring finger protein 7. | 0.434 |
DCUN1D2 | UBA3 | ENSBTAP00000024848 | ENSBTAP00000071509 | DCN1-like protein. | Ubiquitin like modifier activating enzyme 3. | 0.767 |
DCUN1D2 | UBE2F | ENSBTAP00000024848 | ENSBTAP00000036864 | DCN1-like protein. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.909 |
DCUN1D3 | DCUN1D2 | ENSBTAP00000043119 | ENSBTAP00000024848 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. | DCN1-like protein. | 0.466 |
DCUN1D3 | DCUN1D5 | ENSBTAP00000043119 | ENSBTAP00000004020 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. | DCN1-like protein 5. | 0.493 |
DCUN1D3 | NAE1 | ENSBTAP00000043119 | ENSBTAP00000013367 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.606 |
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