node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL10 | CARD10 | ENSBTAP00000018398 | ENSBTAP00000020024 | BCL10 immune signaling adaptor. | Caspase recruitment domain family member 10. | 0.774 |
BCL10 | CARD11 | ENSBTAP00000018398 | ENSBTAP00000067762 | BCL10 immune signaling adaptor. | Caspase recruitment domain family member 11. | 0.999 |
BCL10 | CARD14 | ENSBTAP00000018398 | ENSBTAP00000068087 | BCL10 immune signaling adaptor. | Caspase recruitment domain family member 14. | 0.666 |
BCL10 | CD79B | ENSBTAP00000018398 | ENSBTAP00000053195 | BCL10 immune signaling adaptor. | CD79b molecule. | 0.403 |
BCL10 | IKBKB | ENSBTAP00000018398 | ENSBTAP00000074208 | BCL10 immune signaling adaptor. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.984 |
BCL10 | IKBKG | ENSBTAP00000018398 | ENSBTAP00000008224 | BCL10 immune signaling adaptor. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.993 |
BCL10 | MALT1 | ENSBTAP00000018398 | ENSBTAP00000043692 | BCL10 immune signaling adaptor. | MALT1 paracaspase. | 0.999 |
BCL10 | PRKCB | ENSBTAP00000018398 | ENSBTAP00000027870 | BCL10 immune signaling adaptor. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.749 |
BCL10 | PRKCQ | ENSBTAP00000018398 | ENSBTAP00000053216 | BCL10 immune signaling adaptor. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.801 |
BCL10 | TRAF6 | ENSBTAP00000018398 | ENSBTAP00000021630 | BCL10 immune signaling adaptor. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.963 |
CARD10 | BCL10 | ENSBTAP00000020024 | ENSBTAP00000018398 | Caspase recruitment domain family member 10. | BCL10 immune signaling adaptor. | 0.774 |
CARD10 | CARD11 | ENSBTAP00000020024 | ENSBTAP00000067762 | Caspase recruitment domain family member 10. | Caspase recruitment domain family member 11. | 0.913 |
CARD10 | CARD14 | ENSBTAP00000020024 | ENSBTAP00000068087 | Caspase recruitment domain family member 10. | Caspase recruitment domain family member 14. | 0.922 |
CARD10 | MALT1 | ENSBTAP00000020024 | ENSBTAP00000043692 | Caspase recruitment domain family member 10. | MALT1 paracaspase. | 0.440 |
CARD10 | PRKCB | ENSBTAP00000020024 | ENSBTAP00000027870 | Caspase recruitment domain family member 10. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.908 |
CARD10 | PRKCQ | ENSBTAP00000020024 | ENSBTAP00000053216 | Caspase recruitment domain family member 10. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.967 |
CARD11 | BCL10 | ENSBTAP00000067762 | ENSBTAP00000018398 | Caspase recruitment domain family member 11. | BCL10 immune signaling adaptor. | 0.999 |
CARD11 | CARD10 | ENSBTAP00000067762 | ENSBTAP00000020024 | Caspase recruitment domain family member 11. | Caspase recruitment domain family member 10. | 0.913 |
CARD11 | CARD14 | ENSBTAP00000067762 | ENSBTAP00000068087 | Caspase recruitment domain family member 11. | Caspase recruitment domain family member 14. | 0.918 |
CARD11 | CD79B | ENSBTAP00000067762 | ENSBTAP00000053195 | Caspase recruitment domain family member 11. | CD79b molecule. | 0.786 |