node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AXIN1 | AXIN2 | ENSBTAP00000067751 | ENSBTAP00000040177 | Axin 1. | Axin 2. | 0.862 |
AXIN1 | RNF146 | ENSBTAP00000067751 | ENSBTAP00000037915 | Axin 1. | E3 ubiquitin-protein ligase RNF146-B; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP- ribosylated prot [...] | 0.827 |
AXIN1 | TNKS | ENSBTAP00000067751 | ENSBTAP00000001917 | Axin 1. | Poly [ADP-ribose] polymerase. | 0.980 |
AXIN1 | TNKS2 | ENSBTAP00000067751 | ENSBTAP00000062142 | Axin 1. | Poly [ADP-ribose] polymerase. | 0.956 |
AXIN2 | AXIN1 | ENSBTAP00000040177 | ENSBTAP00000067751 | Axin 2. | Axin 1. | 0.862 |
AXIN2 | RNF146 | ENSBTAP00000040177 | ENSBTAP00000037915 | Axin 2. | E3 ubiquitin-protein ligase RNF146-B; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP- ribosylated prot [...] | 0.804 |
AXIN2 | TNKS | ENSBTAP00000040177 | ENSBTAP00000001917 | Axin 2. | Poly [ADP-ribose] polymerase. | 0.974 |
AXIN2 | TNKS2 | ENSBTAP00000040177 | ENSBTAP00000062142 | Axin 2. | Poly [ADP-ribose] polymerase. | 0.969 |
BLZF1 | RNF146 | ENSBTAP00000074240 | ENSBTAP00000037915 | Basic leucine zipper nuclear factor 1. | E3 ubiquitin-protein ligase RNF146-B; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP- ribosylated prot [...] | 0.652 |
BLZF1 | TNKS | ENSBTAP00000074240 | ENSBTAP00000001917 | Basic leucine zipper nuclear factor 1. | Poly [ADP-ribose] polymerase. | 0.503 |
BLZF1 | TNKS2 | ENSBTAP00000074240 | ENSBTAP00000062142 | Basic leucine zipper nuclear factor 1. | Poly [ADP-ribose] polymerase. | 0.473 |
CHFR | PARG | ENSBTAP00000018544 | ENSBTAP00000031225 | Checkpoint with forkhead and ring finger domains. | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | 0.571 |
CHFR | PARP1 | ENSBTAP00000018544 | ENSBTAP00000059409 | Checkpoint with forkhead and ring finger domains. | Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF an [...] | 0.755 |
CHFR | PARP2 | ENSBTAP00000018544 | ENSBTAP00000055616 | Checkpoint with forkhead and ring finger domains. | Poly [ADP-ribose] polymerase. | 0.638 |
CHFR | RNF146 | ENSBTAP00000018544 | ENSBTAP00000037915 | Checkpoint with forkhead and ring finger domains. | E3 ubiquitin-protein ligase RNF146-B; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP- ribosylated prot [...] | 0.664 |
CHFR | UBE2D1 | ENSBTAP00000018544 | ENSBTAP00000051358 | Checkpoint with forkhead and ring finger domains. | Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short- lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto- ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1- associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates pol [...] | 0.404 |
PARG | CHFR | ENSBTAP00000031225 | ENSBTAP00000018544 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | Checkpoint with forkhead and ring finger domains. | 0.571 |
PARG | PARP1 | ENSBTAP00000031225 | ENSBTAP00000059409 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF an [...] | 0.976 |
PARG | PARP2 | ENSBTAP00000031225 | ENSBTAP00000055616 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | Poly [ADP-ribose] polymerase. | 0.983 |
PARG | RNF146 | ENSBTAP00000031225 | ENSBTAP00000037915 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental ac [...] | E3 ubiquitin-protein ligase RNF146-B; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP- ribosylated prot [...] | 0.710 |