node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG4 | DDHD2 | ENSBTAP00000017468 | ENSBTAP00000017473 | BCL2 associated athanogene 4. | DDHD domain containing 2. | 0.729 |
BAG4 | LSM1 | ENSBTAP00000017468 | ENSBTAP00000002113 | BCL2 associated athanogene 4. | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | 0.719 |
BAG4 | PLPBP | ENSBTAP00000017468 | ENSBTAP00000039600 | BCL2 associated athanogene 4. | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.693 |
BAG4 | TM2D2 | ENSBTAP00000017468 | ENSBTAP00000004567 | BCL2 associated athanogene 4. | TM2 domain-containing protein 2. | 0.568 |
DDHD2 | BAG4 | ENSBTAP00000017473 | ENSBTAP00000017468 | DDHD domain containing 2. | BCL2 associated athanogene 4. | 0.729 |
DDHD2 | ERLIN2 | ENSBTAP00000017473 | ENSBTAP00000066190 | DDHD domain containing 2. | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). | 0.613 |
DDHD2 | LSM1 | ENSBTAP00000017473 | ENSBTAP00000002113 | DDHD domain containing 2. | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | 0.707 |
DDHD2 | PLPBP | ENSBTAP00000017473 | ENSBTAP00000039600 | DDHD domain containing 2. | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.724 |
DDHD2 | TM2D2 | ENSBTAP00000017473 | ENSBTAP00000004567 | DDHD domain containing 2. | TM2 domain-containing protein 2. | 0.747 |
ERLIN2 | DDHD2 | ENSBTAP00000066190 | ENSBTAP00000017473 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). | DDHD domain containing 2. | 0.613 |
ERLIN2 | PLPBP | ENSBTAP00000066190 | ENSBTAP00000039600 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.732 |
ERLIN2 | TM2D2 | ENSBTAP00000066190 | ENSBTAP00000004567 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). | TM2 domain-containing protein 2. | 0.587 |
LACC1 | PLPBP | ENSBTAP00000022192 | ENSBTAP00000039600 | Uncharacterized protein. | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.847 |
LRRC59 | PLPBP | ENSBTAP00000007978 | ENSBTAP00000039600 | Leucine-rich repeat-containing protein 59, N-terminally processed; Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.636 |
LRRC59 | RASSF4 | ENSBTAP00000007978 | ENSBTAP00000059510 | Leucine-rich repeat-containing protein 59, N-terminally processed; Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). | Ras association domain family member 4. | 0.635 |
LSM1 | BAG4 | ENSBTAP00000002113 | ENSBTAP00000017468 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | BCL2 associated athanogene 4. | 0.719 |
LSM1 | DDHD2 | ENSBTAP00000002113 | ENSBTAP00000017473 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | DDHD domain containing 2. | 0.707 |
LSM1 | PLPBP | ENSBTAP00000002113 | ENSBTAP00000039600 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.743 |
LSM1 | TM2D2 | ENSBTAP00000002113 | ENSBTAP00000004567 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | TM2 domain-containing protein 2. | 0.678 |
PDXK | PLPBP | ENSBTAP00000024203 | ENSBTAP00000039600 | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6. | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.851 |