node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BIRC3 | CASP8 | ENSBTAP00000034604 | ENSBTAP00000062824 | Baculoviral IAP repeat-containing 3. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.634 |
BIRC3 | RIPK1 | ENSBTAP00000034604 | ENSBTAP00000008367 | Baculoviral IAP repeat-containing 3. | Receptor (TNFRSF)-interacting serine-threonine kinase 1. | 0.974 |
BIRC3 | TNF | ENSBTAP00000034604 | ENSBTAP00000035682 | Baculoviral IAP repeat-containing 3. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.920 |
BIRC3 | TNFAIP3 | ENSBTAP00000034604 | ENSBTAP00000072859 | Baculoviral IAP repeat-containing 3. | TNF alpha induced protein 3. | 0.887 |
BIRC3 | TNFRSF1A | ENSBTAP00000034604 | ENSBTAP00000071830 | Baculoviral IAP repeat-containing 3. | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). | 0.978 |
BIRC3 | TRADD | ENSBTAP00000034604 | ENSBTAP00000016776 | Baculoviral IAP repeat-containing 3. | Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN [...] | 0.954 |
BIRC3 | TRAF1 | ENSBTAP00000034604 | ENSBTAP00000041215 | Baculoviral IAP repeat-containing 3. | TNF receptor-associated factor. | 0.917 |
BIRC3 | TRAF2 | ENSBTAP00000034604 | ENSBTAP00000013869 | Baculoviral IAP repeat-containing 3. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.975 |
CASP8 | BIRC3 | ENSBTAP00000062824 | ENSBTAP00000034604 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Baculoviral IAP repeat-containing 3. | 0.634 |
CASP8 | MAVS | ENSBTAP00000062824 | ENSBTAP00000071082 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Mitochondrial antiviral signaling protein. | 0.501 |
CASP8 | RIPK1 | ENSBTAP00000062824 | ENSBTAP00000008367 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Receptor (TNFRSF)-interacting serine-threonine kinase 1. | 0.999 |
CASP8 | TNF | ENSBTAP00000062824 | ENSBTAP00000035682 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.971 |
CASP8 | TNFAIP3 | ENSBTAP00000062824 | ENSBTAP00000072859 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | TNF alpha induced protein 3. | 0.539 |
CASP8 | TNFRSF1A | ENSBTAP00000062824 | ENSBTAP00000071830 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). | 0.912 |
CASP8 | TRADD | ENSBTAP00000062824 | ENSBTAP00000016776 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN [...] | 0.999 |
CASP8 | TRAF1 | ENSBTAP00000062824 | ENSBTAP00000041215 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | TNF receptor-associated factor. | 0.966 |
CASP8 | TRAF2 | ENSBTAP00000062824 | ENSBTAP00000013869 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.939 |
MAVS | CASP8 | ENSBTAP00000071082 | ENSBTAP00000062824 | Mitochondrial antiviral signaling protein. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.501 |
MAVS | RIPK1 | ENSBTAP00000071082 | ENSBTAP00000008367 | Mitochondrial antiviral signaling protein. | Receptor (TNFRSF)-interacting serine-threonine kinase 1. | 0.747 |
MAVS | TANK | ENSBTAP00000071082 | ENSBTAP00000043495 | Mitochondrial antiviral signaling protein. | TRAF family member associated NFKB activator. | 0.884 |