node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | CREBBP | ENSBTAP00000036739 | ENSBTAP00000005092 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | CREB binding protein. | 0.661 |
ACTB | PPARG | ENSBTAP00000036739 | ENSBTAP00000041555 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.982 |
ACTB | PPARGC1A | ENSBTAP00000036739 | ENSBTAP00000022636 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.797 |
ACTB | RXRA | ENSBTAP00000036739 | ENSBTAP00000023729 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Retinoid X receptor alpha. | 0.424 |
ACTB | SIRT1 | ENSBTAP00000036739 | ENSBTAP00000018630 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Sirtuin 1. | 0.814 |
CREBBP | ACTB | ENSBTAP00000005092 | ENSBTAP00000036739 | CREB binding protein. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.661 |
CREBBP | NCOA1 | ENSBTAP00000005092 | ENSBTAP00000055281 | CREB binding protein. | Nuclear receptor coactivator. | 0.992 |
CREBBP | NCOR1 | ENSBTAP00000005092 | ENSBTAP00000053758 | CREB binding protein. | Nuclear receptor corepressor 1. | 0.901 |
CREBBP | PPARG | ENSBTAP00000005092 | ENSBTAP00000041555 | CREB binding protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.969 |
CREBBP | PPARGC1A | ENSBTAP00000005092 | ENSBTAP00000022636 | CREB binding protein. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.636 |
CREBBP | RXRA | ENSBTAP00000005092 | ENSBTAP00000023729 | CREB binding protein. | Retinoid X receptor alpha. | 0.928 |
CREBBP | RXRB | ENSBTAP00000005092 | ENSBTAP00000000860 | CREB binding protein. | Retinoid X receptor, beta. | 0.786 |
CREBBP | RXRG | ENSBTAP00000005092 | ENSBTAP00000022350 | CREB binding protein. | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). | 0.829 |
CREBBP | SIRT1 | ENSBTAP00000005092 | ENSBTAP00000018630 | CREB binding protein. | Sirtuin 1. | 0.783 |
NCOA1 | CREBBP | ENSBTAP00000055281 | ENSBTAP00000005092 | Nuclear receptor coactivator. | CREB binding protein. | 0.992 |
NCOA1 | NCOR1 | ENSBTAP00000055281 | ENSBTAP00000053758 | Nuclear receptor coactivator. | Nuclear receptor corepressor 1. | 0.833 |
NCOA1 | PPARG | ENSBTAP00000055281 | ENSBTAP00000041555 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.971 |
NCOA1 | PPARGC1A | ENSBTAP00000055281 | ENSBTAP00000022636 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.654 |
NCOA1 | RXRA | ENSBTAP00000055281 | ENSBTAP00000023729 | Nuclear receptor coactivator. | Retinoid X receptor alpha. | 0.965 |
NCOA1 | RXRB | ENSBTAP00000055281 | ENSBTAP00000000860 | Nuclear receptor coactivator. | Retinoid X receptor, beta. | 0.847 |