node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIMP2 | EPRS1 | ENSBTAP00000009687 | ENSBTAP00000071506 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Glutamyl-prolyl-tRNA synthetase. | 0.998 |
AIMP2 | LARS1 | ENSBTAP00000009687 | ENSBTAP00000008902 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.941 |
AIMP2 | LARS2 | ENSBTAP00000009687 | ENSBTAP00000052354 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.884 |
AIMP2 | MARS1 | ENSBTAP00000009687 | ENSBTAP00000057583 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |
AIMP2 | MARS2 | ENSBTAP00000009687 | ENSBTAP00000042279 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.919 |
AIMP2 | RARS2 | ENSBTAP00000009687 | ENSBTAP00000058548 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.904 |
AIMP2 | YARS1 | ENSBTAP00000009687 | ENSBTAP00000024051 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.879 |
CTH-2 | EPRS1 | ENSBTAP00000062349 | ENSBTAP00000071506 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Glutamyl-prolyl-tRNA synthetase. | 0.453 |
CTH-2 | MARS1 | ENSBTAP00000062349 | ENSBTAP00000057583 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.943 |
CTH-2 | MARS2 | ENSBTAP00000062349 | ENSBTAP00000042279 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.927 |
CTH-2 | MTR | ENSBTAP00000062349 | ENSBTAP00000067894 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.991 |
EPRS1 | AIMP2 | ENSBTAP00000071506 | ENSBTAP00000009687 | Glutamyl-prolyl-tRNA synthetase. | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2- mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. | 0.998 |
EPRS1 | CTH-2 | ENSBTAP00000071506 | ENSBTAP00000062349 | Glutamyl-prolyl-tRNA synthetase. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.453 |
EPRS1 | LARS1 | ENSBTAP00000071506 | ENSBTAP00000008902 | Glutamyl-prolyl-tRNA synthetase. | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |
EPRS1 | LARS2 | ENSBTAP00000071506 | ENSBTAP00000052354 | Glutamyl-prolyl-tRNA synthetase. | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.984 |
EPRS1 | MARS1 | ENSBTAP00000071506 | ENSBTAP00000057583 | Glutamyl-prolyl-tRNA synthetase. | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |
EPRS1 | MARS2 | ENSBTAP00000071506 | ENSBTAP00000042279 | Glutamyl-prolyl-tRNA synthetase. | Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.985 |
EPRS1 | MTFMT | ENSBTAP00000071506 | ENSBTAP00000028820 | Glutamyl-prolyl-tRNA synthetase. | Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism; Belongs to the Fmt family. | 0.528 |
EPRS1 | RARS2 | ENSBTAP00000071506 | ENSBTAP00000058548 | Glutamyl-prolyl-tRNA synthetase. | Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.996 |
EPRS1 | YARS1 | ENSBTAP00000071506 | ENSBTAP00000024051 | Glutamyl-prolyl-tRNA synthetase. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |