STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
KCNAB2Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore- forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarit [...] (415 aa)    
Predicted Functional Partners:
KCNA2
Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family.
   
 0.898
KCNA4
Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well [...]
   
 0.888
KCNA1
Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family.
   
 0.882
KCNA3
Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family.
   
 0.866
KCNA7
Potassium voltage-gated channel subfamily A member 7; Belongs to the potassium channel family.
   
 0.812
KCNA10
Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family.
   
 0.792
KCNH5
Potassium voltage-gated channel subfamily H member 5.
    
 0.786
KCNC1
Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family.
   
 0.785
KCNC3
Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family.
   
 0.781
KCNB1
Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family.
   
 0.774
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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