STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC12A1Solute carrier family 12 member 1. (1099 aa)    
Predicted Functional Partners:
KCNJ1
Potassium voltage-gated channel subfamily J member 1.
   
  
 0.800
NPHS2
NPHS2 stomatin family member, podocin.
   
  
 0.749
NPHS1
NPHS1 adhesion molecule, nephrin.
      
 0.746
AQP2
Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.742
UMOD
Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
   
 
 0.713
SLC34A1
Solute carrier family 34 member 1.
   
  
 0.700
BSND
Barttin CLCNK type accessory beta subunit.
   
  
 0.610
SLC3A1
Solute carrier family 3 member 1.
   
 
 0.599
G1K1P6_BOVIN
Uncharacterized protein.
      
 0.576
RBP5
Retinol-binding protein 5; Intracellular transport of retinol. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
      
 0.574
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.