STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALX4Homeobox protein aristaless-like 4; Transcription factor involved in skull and limb development. (397 aa)    
Predicted Functional Partners:
GLI3
GLI family zinc finger 3.
  
 
 
 0.643
PHIP
Pleckstrin homology domain interacting protein.
    
 
 0.628
HINT2
Histidine triad nucleotide-binding protein 2, mitochondrial; Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity); Belongs to the HINT family.
      
 0.608
EXT2
Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan.
      
 0.600
GTF2A1
General transcription factor IIA subunit 1.
      
 0.593
NEURL2
Neuralized E3 ubiquitin protein ligase 2.
      
 0.592
HAND2
Heart and neural crest derivatives expressed 2.
    
 
 0.563
IRAK1BP1
Interleukin 1 receptor associated kinase 1 binding protein 1.
      
 0.558
PPFIA2
PTPRF interacting protein alpha 2.
      
 0.549
SPATA25
Spermatogenesis associated 25.
      
 0.511
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.