node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDOA | ENO1 | ENSBTAP00000057869 | ENSBTAP00000017839 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | 0.979 |
ALDOA | ENO2 | ENSBTAP00000057869 | ENSBTAP00000014978 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | ENO2 protein. | 0.962 |
ALDOA | ENO3 | ENSBTAP00000057869 | ENSBTAP00000063298 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.976 |
ALDOA | ENO4 | ENSBTAP00000057869 | ENSBTAP00000043066 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Enolase 4. | 0.946 |
ALDOA | GPI | ENSBTAP00000057869 | ENSBTAP00000073190 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | 0.985 |
ALDOA | HIF1A | ENSBTAP00000057869 | ENSBTAP00000027885 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...] | 0.577 |
ALDOA | LDHA | ENSBTAP00000057869 | ENSBTAP00000047729 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | L-lactate dehydrogenase A chain. | 0.967 |
ALDOA | LDHB | ENSBTAP00000057869 | ENSBTAP00000069027 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. | 0.948 |
ALDOA | LDHC | ENSBTAP00000057869 | ENSBTAP00000003234 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.929 |
ALDOA | PKM | ENSBTAP00000057869 | ENSBTAP00000044619 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.983 |
ENO1 | ALDOA | ENSBTAP00000017839 | ENSBTAP00000057869 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | 0.979 |
ENO1 | ENO2 | ENSBTAP00000017839 | ENSBTAP00000014978 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | ENO2 protein. | 0.672 |
ENO1 | ENO3 | ENSBTAP00000017839 | ENSBTAP00000063298 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.667 |
ENO1 | ENO4 | ENSBTAP00000017839 | ENSBTAP00000043066 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | Enolase 4. | 0.689 |
ENO1 | GPI | ENSBTAP00000017839 | ENSBTAP00000073190 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | 0.989 |
ENO1 | HIF1A | ENSBTAP00000017839 | ENSBTAP00000027885 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...] | 0.651 |
ENO1 | LDHA | ENSBTAP00000017839 | ENSBTAP00000047729 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | L-lactate dehydrogenase A chain. | 0.896 |
ENO1 | LDHB | ENSBTAP00000017839 | ENSBTAP00000069027 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. | 0.802 |
ENO1 | LDHC | ENSBTAP00000017839 | ENSBTAP00000003234 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.708 |
ENO1 | PKM | ENSBTAP00000017839 | ENSBTAP00000044619 | Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.996 |