node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KAT2A | SGF29 | ENSBTAP00000053430 | ENSBTAP00000022457 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | SGF29 C-terminal domain-containing protein. | 0.955 |
KAT2A | SUPT3H | ENSBTAP00000053430 | ENSBTAP00000074033 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | SPT3 homolog, SAGA and STAGA complex component. | 0.952 |
KAT2A | TADA2A | ENSBTAP00000053430 | ENSBTAP00000019537 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA [...] | 0.951 |
KAT2A | TADA2B | ENSBTAP00000053430 | ENSBTAP00000056462 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Transcriptional adapter. | 0.977 |
KAT2A | TADA3 | ENSBTAP00000053430 | ENSBTAP00000044929 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). | 0.992 |
KAT2A | TAF10 | ENSBTAP00000053430 | ENSBTAP00000000926 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. | 0.980 |
KAT2A | TAF12 | ENSBTAP00000053430 | ENSBTAP00000068815 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Transcription initiation factor TFIID subunit 12; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity); Belongs to the TAF12 family. | 0.922 |
KAT2A | TAF6 | ENSBTAP00000053430 | ENSBTAP00000057288 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | TATA-box binding protein associated factor 6. | 0.886 |
KAT2A | TRRAP | ENSBTAP00000053430 | ENSBTAP00000009365 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.987 |
KAT2A | USP22 | ENSBTAP00000053430 | ENSBTAP00000011818 | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity); Belongs to the peptidase C19 family. UBP8 subfamily. | 0.960 |
SGF29 | KAT2A | ENSBTAP00000022457 | ENSBTAP00000053430 | SGF29 C-terminal domain-containing protein. | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. | 0.955 |
SGF29 | SUPT3H | ENSBTAP00000022457 | ENSBTAP00000074033 | SGF29 C-terminal domain-containing protein. | SPT3 homolog, SAGA and STAGA complex component. | 0.989 |
SGF29 | TADA2A | ENSBTAP00000022457 | ENSBTAP00000019537 | SGF29 C-terminal domain-containing protein. | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA [...] | 0.992 |
SGF29 | TADA2B | ENSBTAP00000022457 | ENSBTAP00000056462 | SGF29 C-terminal domain-containing protein. | Transcriptional adapter. | 0.981 |
SGF29 | TADA3 | ENSBTAP00000022457 | ENSBTAP00000044929 | SGF29 C-terminal domain-containing protein. | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). | 0.999 |
SGF29 | TAF10 | ENSBTAP00000022457 | ENSBTAP00000000926 | SGF29 C-terminal domain-containing protein. | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. | 0.987 |
SGF29 | TAF12 | ENSBTAP00000022457 | ENSBTAP00000068815 | SGF29 C-terminal domain-containing protein. | Transcription initiation factor TFIID subunit 12; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity); Belongs to the TAF12 family. | 0.988 |
SGF29 | TAF6 | ENSBTAP00000022457 | ENSBTAP00000057288 | SGF29 C-terminal domain-containing protein. | TATA-box binding protein associated factor 6. | 0.936 |
SGF29 | TRRAP | ENSBTAP00000022457 | ENSBTAP00000009365 | SGF29 C-terminal domain-containing protein. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.992 |
SGF29 | USP22 | ENSBTAP00000022457 | ENSBTAP00000011818 | SGF29 C-terminal domain-containing protein. | Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity); Belongs to the peptidase C19 family. UBP8 subfamily. | 0.954 |