STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITIH5Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor; Belongs to the ITIH family. (940 aa)    
Predicted Functional Partners:
RASAL3
RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway.
    
 
 0.655
GLOD5
Glyoxalase domain containing 5.
   
 
 0.628
TNFAIP6
Tumor necrosis factor, alpha-induced protein 6.
   
 
 0.605
GOLGA1
Golgin A1.
   
 
 0.568
ANKRD16
Ankyrin repeat domain 16.
    
 
 0.548
RASGEF1B
Ras-GEF domain-containing family member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
      
 0.541
OGFOD1
Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family.
   
  
 0.517
PRELP
Prolargin; May anchor basement membranes to the underlying connective tissue; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
   
 
 0.508
HOXD10
HOXD10 protein.
    
 
 0.501
PPFIBP2
PPFIA binding protein 2.
      
 0.497
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.