node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA11 | ANXA7 | ENSBTAP00000027893 | ENSBTAP00000065090 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.909 |
ANXA11 | CASP3 | ENSBTAP00000027893 | ENSBTAP00000021099 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.563 |
ANXA11 | EGFR | ENSBTAP00000027893 | ENSBTAP00000070620 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | Receptor protein-tyrosine kinase. | 0.469 |
ANXA11 | GAPDH | ENSBTAP00000027893 | ENSBTAP00000062798 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.535 |
ANXA11 | PEF1 | ENSBTAP00000027893 | ENSBTAP00000013699 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | Penta-EF-hand domain containing 1. | 0.763 |
ANXA11 | TSG101 | ENSBTAP00000027893 | ENSBTAP00000018032 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | Tumor susceptibility 101. | 0.617 |
ANXA7 | ANXA11 | ENSBTAP00000065090 | ENSBTAP00000027893 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | 0.909 |
ANXA7 | CASP3 | ENSBTAP00000065090 | ENSBTAP00000021099 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.584 |
ANXA7 | EGFR | ENSBTAP00000065090 | ENSBTAP00000070620 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Receptor protein-tyrosine kinase. | 0.536 |
ANXA7 | GAPDH | ENSBTAP00000065090 | ENSBTAP00000062798 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.531 |
ANXA7 | GCA | ENSBTAP00000065090 | ENSBTAP00000024550 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Grancalcin. | 0.640 |
ANXA7 | MROH7 | ENSBTAP00000065090 | ENSBTAP00000053490 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Uncharacterized protein. | 0.568 |
ANXA7 | PEF1 | ENSBTAP00000065090 | ENSBTAP00000013699 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Penta-EF-hand domain containing 1. | 0.658 |
ANXA7 | PRDX6 | ENSBTAP00000065090 | ENSBTAP00000006383 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.519 |
ANXA7 | SRI | ENSBTAP00000065090 | ENSBTAP00000052219 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Sorcin. | 0.810 |
ANXA7 | TSG101 | ENSBTAP00000065090 | ENSBTAP00000018032 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Tumor susceptibility 101. | 0.543 |
CASP3 | ANXA11 | ENSBTAP00000021099 | ENSBTAP00000027893 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family. | 0.563 |
CASP3 | ANXA7 | ENSBTAP00000021099 | ENSBTAP00000065090 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.584 |
CASP3 | EGFR | ENSBTAP00000021099 | ENSBTAP00000070620 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Receptor protein-tyrosine kinase. | 0.799 |
CASP3 | GAPDH | ENSBTAP00000021099 | ENSBTAP00000062798 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.905 |