node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASDH | CYP11B1 | ENSBTAP00000068886 | ENSBTAP00000047946 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | 0.549 |
AASDH | CYP17A1 | ENSBTAP00000068886 | ENSBTAP00000062923 | Aminoadipate-semialdehyde dehydrogenase. | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | 0.545 |
AASDH | CYP26C1 | ENSBTAP00000068886 | ENSBTAP00000050244 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. | 0.490 |
AASDH | F1MG97_BOVIN | ENSBTAP00000068886 | ENSBTAP00000048098 | Aminoadipate-semialdehyde dehydrogenase. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.503 |
AASDH | G3X6I9_BOVIN | ENSBTAP00000068886 | ENSBTAP00000007353 | Aminoadipate-semialdehyde dehydrogenase. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.490 |
AASDH | LOC112441470 | ENSBTAP00000068886 | ENSBTAP00000019061 | Aminoadipate-semialdehyde dehydrogenase. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.524 |
AASDH | LOC112444495 | ENSBTAP00000068886 | ENSBTAP00000069265 | Aminoadipate-semialdehyde dehydrogenase. | Steroid 17-alpha-hydroxylase/17,20 lyase. | 0.490 |
AASDH | LOC112449566 | ENSBTAP00000068886 | ENSBTAP00000006034 | Aminoadipate-semialdehyde dehydrogenase. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.503 |
CYP11B1 | AASDH | ENSBTAP00000047946 | ENSBTAP00000068886 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Aminoadipate-semialdehyde dehydrogenase. | 0.549 |
CYP11B1 | CYP17A1 | ENSBTAP00000047946 | ENSBTAP00000062923 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | 0.665 |
CYP11B1 | CYP26C1 | ENSBTAP00000047946 | ENSBTAP00000050244 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. | 0.512 |
CYP11B1 | F1MG97_BOVIN | ENSBTAP00000047946 | ENSBTAP00000048098 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.404 |
CYP11B1 | FDX1 | ENSBTAP00000047946 | ENSBTAP00000015660 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. | 0.749 |
CYP11B1 | FDX2 | ENSBTAP00000047946 | ENSBTAP00000013630 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.430 |
CYP11B1 | G3X6I9_BOVIN | ENSBTAP00000047946 | ENSBTAP00000007353 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.450 |
CYP11B1 | LOC112441470 | ENSBTAP00000047946 | ENSBTAP00000019061 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.963 |
CYP11B1 | LOC112444495 | ENSBTAP00000047946 | ENSBTAP00000069265 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Steroid 17-alpha-hydroxylase/17,20 lyase. | 0.634 |
CYP11B1 | LOC112449566 | ENSBTAP00000047946 | ENSBTAP00000006034 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.405 |
CYP17A1 | AASDH | ENSBTAP00000062923 | ENSBTAP00000068886 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Aminoadipate-semialdehyde dehydrogenase. | 0.545 |
CYP17A1 | CYP11B1 | ENSBTAP00000062923 | ENSBTAP00000047946 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | 0.665 |