node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASS | ALDH7A1 | ENSBTAP00000016090 | ENSBTAP00000048297 | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity). | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.957 |
ABAT | ACSS2 | ENSBTAP00000005280 | ENSBTAP00000067480 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acyl-CoA synthetase short chain family member 2. | 0.829 |
ABAT | AGXT2 | ENSBTAP00000005280 | ENSBTAP00000010113 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.934 |
ABAT | ALDH7A1 | ENSBTAP00000005280 | ENSBTAP00000048297 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.944 |
ABAT | GADL1 | ENSBTAP00000005280 | ENSBTAP00000009385 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acidic amino acid decarboxylase GADL1; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L- aspartate. Does not exhibit any decarboxylation activity toward glutamate. | 0.940 |
ACSS2 | ABAT | ENSBTAP00000067480 | ENSBTAP00000005280 | Acyl-CoA synthetase short chain family member 2. | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.829 |
ACSS2 | AGXT2 | ENSBTAP00000067480 | ENSBTAP00000010113 | Acyl-CoA synthetase short chain family member 2. | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.829 |
ACSS2 | ALDH7A1 | ENSBTAP00000067480 | ENSBTAP00000048297 | Acyl-CoA synthetase short chain family member 2. | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.951 |
ADH4 | ADH5 | ENSBTAP00000003769 | ENSBTAP00000021304 | PKS_ER domain-containing protein. | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.903 |
ADH4 | ADH6 | ENSBTAP00000003769 | ENSBTAP00000009191 | PKS_ER domain-containing protein. | Uncharacterized protein. | 0.911 |
ADH4 | ALDH7A1 | ENSBTAP00000003769 | ENSBTAP00000048297 | PKS_ER domain-containing protein. | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.948 |
ADH5 | ADH4 | ENSBTAP00000021304 | ENSBTAP00000003769 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | PKS_ER domain-containing protein. | 0.903 |
ADH5 | ADH6 | ENSBTAP00000021304 | ENSBTAP00000009191 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Uncharacterized protein. | 0.902 |
ADH5 | ALDH7A1 | ENSBTAP00000021304 | ENSBTAP00000048297 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.957 |
ADH6 | ADH4 | ENSBTAP00000009191 | ENSBTAP00000003769 | Uncharacterized protein. | PKS_ER domain-containing protein. | 0.911 |
ADH6 | ADH5 | ENSBTAP00000009191 | ENSBTAP00000021304 | Uncharacterized protein. | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.902 |
ADH6 | ALDH7A1 | ENSBTAP00000009191 | ENSBTAP00000048297 | Uncharacterized protein. | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.952 |
AGXT2 | ABAT | ENSBTAP00000010113 | ENSBTAP00000005280 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.934 |
AGXT2 | ACSS2 | ENSBTAP00000010113 | ENSBTAP00000067480 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Acyl-CoA synthetase short chain family member 2. | 0.829 |
AGXT2 | ALDH7A1 | ENSBTAP00000010113 | ENSBTAP00000048297 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family. | 0.950 |