STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASC4Protein CASC4. (443 aa)    
Predicted Functional Partners:
CASC3
Protein CASC3; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs th [...]
      
 0.684
SUPT3H
SPT3 homolog, SAGA and STAGA complex component.
    
 
 0.606
CCDC134
Coiled-coil domain containing 134.
    
 
 0.585
ZNF554
Zinc finger protein 554.
    
 
 0.577
KCNK13
Potassium two pore domain channel subfamily K member 13; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.577
TTC7B
Tetratricopeptide repeat domain 7B.
      
 0.567
TXNDC12
Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity.
   
 
 0.555
SEC31B
SEC31 homolog B, COPII coat complex component.
      
 0.550
TMED2
GOLD domain-containing protein.
    
 
 0.522
KCNH5
Potassium voltage-gated channel subfamily H member 5.
      
 0.510
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.