node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSA2 | DNAJB5 | ENSBTAP00000050140 | ENSBTAP00000043310 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | DnaJ homolog subfamily B member 5. | 0.732 |
AHSA2 | ENSBTAP00000074523 | ENSBTAP00000050140 | ENSBTAP00000074523 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | TPR_REGION domain-containing protein. | 0.747 |
AHSA2 | HSP90AA1 | ENSBTAP00000050140 | ENSBTAP00000008225 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.762 |
AHSA2 | HSP90AB1 | ENSBTAP00000050140 | ENSBTAP00000072629 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.760 |
AHSA2 | HSP90B1 | ENSBTAP00000050140 | ENSBTAP00000004364 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. | 0.725 |
AHSA2 | NKTR | ENSBTAP00000050140 | ENSBTAP00000030831 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Natural killer cell triggering receptor. | 0.785 |
AHSA2 | PPID | ENSBTAP00000050140 | ENSBTAP00000022180 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Peptidyl-prolyl cis-trans isomerase D; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor co [...] | 0.795 |
AHSA2 | PPIG | ENSBTAP00000050140 | ENSBTAP00000039852 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Peptidylprolyl isomerase G. | 0.785 |
AHSA2 | STIP1 | ENSBTAP00000050140 | ENSBTAP00000059641 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Stress-induced-phosphoprotein 1. | 0.809 |
AHSA2 | STIP1-2 | ENSBTAP00000050140 | ENSBTAP00000059610 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.802 |
DNAJB5 | AHSA2 | ENSBTAP00000043310 | ENSBTAP00000050140 | DnaJ homolog subfamily B member 5. | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | 0.732 |
DNAJB5 | ENSBTAP00000074523 | ENSBTAP00000043310 | ENSBTAP00000074523 | DnaJ homolog subfamily B member 5. | TPR_REGION domain-containing protein. | 0.511 |
DNAJB5 | HSP90AA1 | ENSBTAP00000043310 | ENSBTAP00000008225 | DnaJ homolog subfamily B member 5. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.463 |
DNAJB5 | HSP90AB1 | ENSBTAP00000043310 | ENSBTAP00000072629 | DnaJ homolog subfamily B member 5. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.504 |
DNAJB5 | NKTR | ENSBTAP00000043310 | ENSBTAP00000030831 | DnaJ homolog subfamily B member 5. | Natural killer cell triggering receptor. | 0.608 |
DNAJB5 | PPID | ENSBTAP00000043310 | ENSBTAP00000022180 | DnaJ homolog subfamily B member 5. | Peptidyl-prolyl cis-trans isomerase D; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor co [...] | 0.608 |
DNAJB5 | PPIG | ENSBTAP00000043310 | ENSBTAP00000039852 | DnaJ homolog subfamily B member 5. | Peptidylprolyl isomerase G. | 0.608 |
DNAJB5 | STIP1 | ENSBTAP00000043310 | ENSBTAP00000059641 | DnaJ homolog subfamily B member 5. | Stress-induced-phosphoprotein 1. | 0.511 |
DNAJB5 | STIP1-2 | ENSBTAP00000043310 | ENSBTAP00000059610 | DnaJ homolog subfamily B member 5. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.542 |
ENSBTAP00000074523 | AHSA2 | ENSBTAP00000074523 | ENSBTAP00000050140 | TPR_REGION domain-containing protein. | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. | 0.747 |