Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1S1 | DEPTOR | ENSBTAP00000007575 | ENSBTAP00000061795 | AKT1 substrate 1. | DEP domain containing MTOR interacting protein. | 0.953 |
| AKT1S1 | MLST8 | ENSBTAP00000007575 | ENSBTAP00000013104 | AKT1 substrate 1. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.988 |
| AKT1S1 | MTOR | ENSBTAP00000007575 | ENSBTAP00000020386 | AKT1 substrate 1. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.995 |
| AKT1S1 | RHEB | ENSBTAP00000007575 | ENSBTAP00000050644 | AKT1 substrate 1. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity (By similarity). | 0.950 |
| AKT1S1 | RPTOR | ENSBTAP00000007575 | ENSBTAP00000003739 | AKT1 substrate 1. | Regulatory associated protein of MTOR complex 1. | 0.998 |
| AKT1S1 | RRAGA | ENSBTAP00000007575 | ENSBTAP00000051093 | AKT1 substrate 1. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.829 |
| AKT1S1 | TSC2 | ENSBTAP00000007575 | ENSBTAP00000046373 | AKT1 substrate 1. | TSC complex subunit 2. | 0.599 |
| BNIP3 | RHEB | ENSBTAP00000023684 | ENSBTAP00000050644 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mito [...] | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity (By similarity). | 0.988 |
| DEPTOR | AKT1S1 | ENSBTAP00000061795 | ENSBTAP00000007575 | DEP domain containing MTOR interacting protein. | AKT1 substrate 1. | 0.953 |
| DEPTOR | MLST8 | ENSBTAP00000061795 | ENSBTAP00000013104 | DEP domain containing MTOR interacting protein. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
| DEPTOR | MTOR | ENSBTAP00000061795 | ENSBTAP00000020386 | DEP domain containing MTOR interacting protein. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.992 |
| DEPTOR | RHEB | ENSBTAP00000061795 | ENSBTAP00000050644 | DEP domain containing MTOR interacting protein. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity (By similarity). | 0.984 |
| DEPTOR | RPTOR | ENSBTAP00000061795 | ENSBTAP00000003739 | DEP domain containing MTOR interacting protein. | Regulatory associated protein of MTOR complex 1. | 0.999 |
| DEPTOR | RRAGA | ENSBTAP00000061795 | ENSBTAP00000051093 | DEP domain containing MTOR interacting protein. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.910 |
| DEPTOR | TBC1D7 | ENSBTAP00000061795 | ENSBTAP00000022819 | DEP domain containing MTOR interacting protein. | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is un [...] | 0.500 |
| DEPTOR | TSC1 | ENSBTAP00000061795 | ENSBTAP00000006842 | DEP domain containing MTOR interacting protein. | TSC complex subunit 1. | 0.451 |
| DEPTOR | TSC2 | ENSBTAP00000061795 | ENSBTAP00000046373 | DEP domain containing MTOR interacting protein. | TSC complex subunit 2. | 0.758 |
| MLST8 | AKT1S1 | ENSBTAP00000013104 | ENSBTAP00000007575 | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | AKT1 substrate 1. | 0.988 |
| MLST8 | DEPTOR | ENSBTAP00000013104 | ENSBTAP00000061795 | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | DEP domain containing MTOR interacting protein. | 0.999 |
| MLST8 | MTOR | ENSBTAP00000013104 | ENSBTAP00000020386 | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.998 |
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