STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCKHCK proto-oncogene, Src family tyrosine kinase (524 aa)    
Predicted Functional Partners:
FCGR1A
Bos taurus Fc fragment of IgG, high affinity Ia, receptor (CD64) (FCGR1A), mRNA
   
 0.965
FCGR3A
Low affinity immunoglobulin gamma Fc region receptor III; Is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Also mediates antibody- dependent cellular toxicity (By similarity)
   
 0.962
CBL
Cbl proto-oncogene, E3 ubiquitin protein ligase
    
 0.950
PIK3CB
Uncharacterized protein; Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family
   
 0.945
SYK
Bos taurus spleen tyrosine kinase (SYK), mRNA
   
0.943
LYN
LYN proto-oncogene, Src family tyrosine kinase
  
 
0.941
GRB2
Bos taurus growth factor receptor-bound protein 2 (GRB2), mRNA
   
0.940
PIK3CD
Uncharacterized protein; Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; Belongs to the PI3/PI4-kinase family
   
  0.938
FCGR2C
Fc-gamma-RII-D; Bos taurus Fc fragment of IgG, low affinity IIc, receptor for (CD32) (FCGR2C), mRNA
   
 0.935
FCGR2B
Bos taurus Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2), mRNA
   
 0.931
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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