STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCMF1E3 ubiquitin-protein ligase KCMF1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination; Belongs to the KCMF1 family. (381 aa)    
Predicted Functional Partners:
UBR4
Ubiquitin protein ligase E3 component n-recognin 4.
    
 
 0.972
THSD7A
Thrombospondin type 1 domain containing 7A.
      
 0.701
CUL3
Cullin 3; Belongs to the cullin family.
   
  
 0.690
MANBAL
Mannosidase, beta A, lysosomal-like.
      
 0.677
ZNF574
Zinc finger protein 574; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
    
 
 0.673
ISCU
Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
      
 0.671
BTBD1
BTB domain containing 1.
   
  
 0.599
THNSL2
Threonine synthase like 2.
      
 0.592
PTPRS
Protein tyrosine phosphatase receptor type S.
      
 0.587
PTPN14
Protein tyrosine phosphatase non-receptor type 14.
      
 0.573
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.