node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCT5 | GNB5 | ENSBTAP00000023778 | ENSBTAP00000004896 | Chaperonin containing TCP1 subunit 5; Belongs to the TCP-1 chaperonin family. | G protein subunit beta 5. | 0.920 |
CCT5 | RGS11 | ENSBTAP00000023778 | ENSBTAP00000022048 | Chaperonin containing TCP1 subunit 5; Belongs to the TCP-1 chaperonin family. | Regulator of G protein signaling 11. | 0.695 |
CCT5 | RGS7 | ENSBTAP00000023778 | ENSBTAP00000051949 | Chaperonin containing TCP1 subunit 5; Belongs to the TCP-1 chaperonin family. | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. | 0.795 |
GNB5 | CCT5 | ENSBTAP00000004896 | ENSBTAP00000023778 | G protein subunit beta 5. | Chaperonin containing TCP1 subunit 5; Belongs to the TCP-1 chaperonin family. | 0.920 |
GNB5 | GPR158 | ENSBTAP00000004896 | ENSBTAP00000032818 | G protein subunit beta 5. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.779 |
GNB5 | LRIT3 | ENSBTAP00000004896 | ENSBTAP00000009238 | G protein subunit beta 5. | Leucine rich repeat, Ig-like and transmembrane domains 3. | 0.527 |
GNB5 | RGS11 | ENSBTAP00000004896 | ENSBTAP00000022048 | G protein subunit beta 5. | Regulator of G protein signaling 11. | 0.917 |
GNB5 | RGS3 | ENSBTAP00000004896 | ENSBTAP00000005904 | G protein subunit beta 5. | Regulator of G protein signaling 3. | 0.664 |
GNB5 | RGS4 | ENSBTAP00000004896 | ENSBTAP00000055609 | G protein subunit beta 5. | Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity). | 0.529 |
GNB5 | RGS7 | ENSBTAP00000004896 | ENSBTAP00000051949 | G protein subunit beta 5. | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. | 0.985 |
GNB5 | RGS7BP | ENSBTAP00000004896 | ENSBTAP00000058084 | G protein subunit beta 5. | Regulator of G-protein signaling 7-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. | 0.636 |
GNB5 | RGS9BP | ENSBTAP00000004896 | ENSBTAP00000048052 | G protein subunit beta 5. | Regulator of G-protein signaling 9-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protectin [...] | 0.883 |
GNB5 | TRPM1 | ENSBTAP00000004896 | ENSBTAP00000010233 | G protein subunit beta 5. | Transient receptor potential cation channel subfamily M member 1. | 0.527 |
GPR158 | GNB5 | ENSBTAP00000032818 | ENSBTAP00000004896 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | G protein subunit beta 5. | 0.779 |
GPR158 | RGS11 | ENSBTAP00000032818 | ENSBTAP00000022048 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Regulator of G protein signaling 11. | 0.930 |
GPR158 | RGS7 | ENSBTAP00000032818 | ENSBTAP00000051949 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. | 0.931 |
GPR158 | RGS7BP | ENSBTAP00000032818 | ENSBTAP00000058084 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Regulator of G-protein signaling 7-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. | 0.679 |
GPR158 | TRPM1 | ENSBTAP00000032818 | ENSBTAP00000010233 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Transient receptor potential cation channel subfamily M member 1. | 0.533 |
LRIT3 | GNB5 | ENSBTAP00000009238 | ENSBTAP00000004896 | Leucine rich repeat, Ig-like and transmembrane domains 3. | G protein subunit beta 5. | 0.527 |
LRIT3 | RGS11 | ENSBTAP00000009238 | ENSBTAP00000022048 | Leucine rich repeat, Ig-like and transmembrane domains 3. | Regulator of G protein signaling 11. | 0.813 |