STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINB4SERPIN domain-containing protein; Belongs to the serpin family. (391 aa)    
Predicted Functional Partners:
LOC505658
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
    
 0.915
E1BAP8_BOVIN
GLOBIN domain-containing protein; Belongs to the globin family.
      
 0.441
KRTAP9-1
Uncharacterized protein.
      
 0.441
E1BDS9_BOVIN
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
    
 
 0.435
ENSBTAP00000059459
14_3_3 domain-containing protein.
    
 
 0.435
ENSBTAP00000064310
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
    
 
 0.435
KLK13
Kallikrein related peptidase 13; Belongs to the peptidase S1 family.
    
 
 0.431
F2
Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family.
   
 
 0.413
S100A12
Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...]
   
 
 0.408
KAT14
Lysine acetyltransferase 14.
    
 
 0.405
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.