STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CETN1Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity); Belongs to the centrin family. (172 aa)    
Predicted Functional Partners:
CEP135
Centrosomal protein 135.
    
 
 0.942
POC5
POC5 centriolar protein.
    
 
 0.903
PCNT
Pericentrin.
    
 0.861
CEP164
Centrosomal protein 164.
    
 
 0.845
SUN5
Sad1 and UNC84 domain containing 5.
   
 
 0.814
PMFBP1
Polyamine modulated factor 1 binding protein 1.
    
 
 0.810
POC1B
POC1 centriolar protein B.
    
 
 0.794
XPC
XPC complex subunit, DNA damage recognition and repair factor.
    
 
 0.782
PLK4
Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...]
    
 
 0.768
IFT88
Intraflagellar transport 88.
    
 0.745
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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