STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SORBS2Uncharacterized protein. (760 aa)    
Predicted Functional Partners:
VTA1
Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity).
    
   0.727
GCH1
GTP cyclohydrolase 1.
    
   0.727
PDLIM3
PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells.
 
  
 
 0.661
VCL
Vinculin.
   
 
 0.659
HSPB7
Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family.
   
  
 0.643
ABHD12B
Abhydrolase domain containing 12B.
      
 0.606
MCTP2
Multiple C2 and transmembrane domain containing 2.
      
 0.591
PDLIM5
PDZ and LIM domain 5.
   
 
 0.587
SNX25
Sorting nexin 25.
      
 0.587
RASL10B
RAS like family 10 member B.
   
 
 0.575
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.