node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRK | CRKL | ENSBTAP00000007443 | ENSBTAP00000055171 | CRK proto-oncogene, adaptor protein. | CRK like proto-oncogene, adaptor protein. | 0.930 |
CRK | KIDINS220 | ENSBTAP00000007443 | ENSBTAP00000053227 | CRK proto-oncogene, adaptor protein. | Kinase D interacting substrate 220. | 0.919 |
CRK | NGF | ENSBTAP00000007443 | ENSBTAP00000058743 | CRK proto-oncogene, adaptor protein. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.634 |
CRK | NTRK1 | ENSBTAP00000007443 | ENSBTAP00000071315 | CRK proto-oncogene, adaptor protein. | Tyrosine-protein kinase receptor. | 0.543 |
CRKL | CRK | ENSBTAP00000055171 | ENSBTAP00000007443 | CRK like proto-oncogene, adaptor protein. | CRK proto-oncogene, adaptor protein. | 0.930 |
CRKL | KIDINS220 | ENSBTAP00000055171 | ENSBTAP00000053227 | CRK like proto-oncogene, adaptor protein. | Kinase D interacting substrate 220. | 0.930 |
CRKL | NGF | ENSBTAP00000055171 | ENSBTAP00000058743 | CRK like proto-oncogene, adaptor protein. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.504 |
CRKL | NTRK1 | ENSBTAP00000055171 | ENSBTAP00000071315 | CRK like proto-oncogene, adaptor protein. | Tyrosine-protein kinase receptor. | 0.578 |
ENSBTAP00000061824 | KIDINS220 | ENSBTAP00000061824 | ENSBTAP00000053227 | Uncharacterized protein. | Kinase D interacting substrate 220. | 0.731 |
KIDINS220 | CRK | ENSBTAP00000053227 | ENSBTAP00000007443 | Kinase D interacting substrate 220. | CRK proto-oncogene, adaptor protein. | 0.919 |
KIDINS220 | CRKL | ENSBTAP00000053227 | ENSBTAP00000055171 | Kinase D interacting substrate 220. | CRK like proto-oncogene, adaptor protein. | 0.930 |
KIDINS220 | ENSBTAP00000061824 | ENSBTAP00000053227 | ENSBTAP00000061824 | Kinase D interacting substrate 220. | Uncharacterized protein. | 0.731 |
KIDINS220 | KLC1 | ENSBTAP00000053227 | ENSBTAP00000023001 | Kinase D interacting substrate 220. | KLC1 protein. | 0.597 |
KIDINS220 | NGF | ENSBTAP00000053227 | ENSBTAP00000058743 | Kinase D interacting substrate 220. | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] | 0.644 |
KIDINS220 | NTRK1 | ENSBTAP00000053227 | ENSBTAP00000071315 | Kinase D interacting substrate 220. | Tyrosine-protein kinase receptor. | 0.914 |
KIDINS220 | OLFM1 | ENSBTAP00000053227 | ENSBTAP00000048556 | Kinase D interacting substrate 220. | Olfactomedin 1. | 0.693 |
KIDINS220 | PRKD3 | ENSBTAP00000053227 | ENSBTAP00000072043 | Kinase D interacting substrate 220. | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.726 |
KIDINS220 | SNX27 | ENSBTAP00000053227 | ENSBTAP00000033754 | Kinase D interacting substrate 220. | Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...] | 0.760 |
KIDINS220 | TBC1D24 | ENSBTAP00000053227 | ENSBTAP00000058291 | Kinase D interacting substrate 220. | TBC1 domain family member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. | 0.625 |
KLC1 | KIDINS220 | ENSBTAP00000023001 | ENSBTAP00000053227 | KLC1 protein. | Kinase D interacting substrate 220. | 0.597 |