node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB6 | ALAD | ENSBTAP00000027459 | ENSBTAP00000000315 | ATP binding cassette subfamily B member 6. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.614 |
ABCB6 | CPOX | ENSBTAP00000027459 | ENSBTAP00000005398 | ATP binding cassette subfamily B member 6. | Coproporphyrinogen oxidase. | 0.716 |
ABCB6 | FECH | ENSBTAP00000027459 | ENSBTAP00000008384 | ATP binding cassette subfamily B member 6. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.809 |
ABCB6 | HMBS | ENSBTAP00000027459 | ENSBTAP00000007052 | ATP binding cassette subfamily B member 6. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.518 |
ABCB6 | PPOX | ENSBTAP00000027459 | ENSBTAP00000053328 | ATP binding cassette subfamily B member 6. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.754 |
ABCB6 | SLC25A38 | ENSBTAP00000027459 | ENSBTAP00000020606 | ATP binding cassette subfamily B member 6. | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | 0.724 |
ABCB6 | UROD | ENSBTAP00000027459 | ENSBTAP00000059516 | ATP binding cassette subfamily B member 6. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.746 |
ABCB6 | UROS | ENSBTAP00000027459 | ENSBTAP00000007615 | ATP binding cassette subfamily B member 6. | Uroporphyrinogen III synthase. | 0.684 |
ALAD | ABCB6 | ENSBTAP00000000315 | ENSBTAP00000027459 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | ATP binding cassette subfamily B member 6. | 0.614 |
ALAD | CPOX | ENSBTAP00000000315 | ENSBTAP00000005398 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Coproporphyrinogen oxidase. | 0.908 |
ALAD | ENDOV | ENSBTAP00000000315 | ENSBTAP00000062292 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Endonuclease V. | 0.544 |
ALAD | FECH | ENSBTAP00000000315 | ENSBTAP00000008384 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.890 |
ALAD | HMBS | ENSBTAP00000000315 | ENSBTAP00000007052 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
ALAD | PPOX | ENSBTAP00000000315 | ENSBTAP00000053328 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.909 |
ALAD | SLC25A38 | ENSBTAP00000000315 | ENSBTAP00000020606 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | 0.608 |
ALAD | UROD | ENSBTAP00000000315 | ENSBTAP00000059516 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.951 |
ALAD | UROS | ENSBTAP00000000315 | ENSBTAP00000007615 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen III synthase. | 0.996 |
CPOX | ABCB6 | ENSBTAP00000005398 | ENSBTAP00000027459 | Coproporphyrinogen oxidase. | ATP binding cassette subfamily B member 6. | 0.716 |
CPOX | ALAD | ENSBTAP00000005398 | ENSBTAP00000000315 | Coproporphyrinogen oxidase. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.908 |
CPOX | ENDOV | ENSBTAP00000005398 | ENSBTAP00000062292 | Coproporphyrinogen oxidase. | Endonuclease V. | 0.877 |