node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP5S1 | SPRN | ENSBTAP00000011104 | ENSBTAP00000054072 | Adaptor related protein complex 5 subunit sigma 1. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.693 |
ECHS1 | SPRN | ENSBTAP00000073344 | ENSBTAP00000054072 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.539 |
PHPT1 | SPRN | ENSBTAP00000068756 | ENSBTAP00000054072 | 14 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.406 |
PRND | PRNP | ENSBTAP00000014624 | ENSBTAP00000069134 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | 0.828 |
PRND | RASSF2 | ENSBTAP00000014624 | ENSBTAP00000023060 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Ras association domain family member 2. | 0.606 |
PRND | SPRN | ENSBTAP00000014624 | ENSBTAP00000054072 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.744 |
PRND | ZP3 | ENSBTAP00000014624 | ENSBTAP00000019756 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. | 0.405 |
PRNP | PRND | ENSBTAP00000069134 | ENSBTAP00000014624 | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.828 |
PRNP | SPRN | ENSBTAP00000069134 | ENSBTAP00000054072 | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.659 |
RARB | SPRN | ENSBTAP00000015305 | ENSBTAP00000054072 | Retinoic acid receptor beta. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.531 |
RASSF2 | PRND | ENSBTAP00000023060 | ENSBTAP00000014624 | Ras association domain family member 2. | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.606 |
RASSF2 | SPRN | ENSBTAP00000023060 | ENSBTAP00000054072 | Ras association domain family member 2. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.532 |
SPRN | AP5S1 | ENSBTAP00000054072 | ENSBTAP00000011104 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Adaptor related protein complex 5 subunit sigma 1. | 0.693 |
SPRN | ECHS1 | ENSBTAP00000054072 | ENSBTAP00000073344 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.539 |
SPRN | PHPT1 | ENSBTAP00000054072 | ENSBTAP00000068756 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 14 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity. | 0.406 |
SPRN | PRND | ENSBTAP00000054072 | ENSBTAP00000014624 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.744 |
SPRN | PRNP | ENSBTAP00000054072 | ENSBTAP00000069134 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | 0.659 |
SPRN | RARB | ENSBTAP00000054072 | ENSBTAP00000015305 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Retinoic acid receptor beta. | 0.531 |
SPRN | RASSF2 | ENSBTAP00000054072 | ENSBTAP00000023060 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Ras association domain family member 2. | 0.532 |
SPRN | SYCE1 | ENSBTAP00000054072 | ENSBTAP00000060304 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. | 0.718 |