STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STX11Bos taurus syntaxin 11 (STX11), mRNA; Belongs to the syntaxin family (287 aa)    
Predicted Functional Partners:
STXBP2
Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family
   
 
 0.907
STX12
STX12 protein; Bos taurus syntaxin 12 (STX12), mRNA; Belongs to the syntaxin family
   
 
 0.894
UNC13D
Unc-13 homolog D (C. elegans)
   
  
 0.886
SNAP23
Bos taurus synaptosomal-associated protein, 23kDa (SNAP23), mRNA; Belongs to the SNAP-25 family
   
 
 0.851
STX19
Syntaxin-19; Bos taurus syntaxin 19 (STX19), mRNA
     
0.812
VAMP3
Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network
   
 
 0.805
VAMP8
Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...]
   
 
 0.799
STX16
Syntaxin 16; Belongs to the syntaxin family
   
 
 0.797
STX8
Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER; Belongs to the syntaxin family
   
 
 0.768
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence
    
 
 0.747
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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