STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AANAT-2Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. Belongs to the acetyltransferase family. AANAT subfamily. (207 aa)    
Predicted Functional Partners:
DDC
Dopa decarboxylase.
     
 0.953
MAOA
Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).
     
 0.934
MAOB
Amine oxidase.
     
 0.929
IDO2
Indoleamine 2,3-dioxygenase 2.
     
 0.924
IDO1
Indoleamine-pyrrole 2,3 dioxygenase.
     
 0.922
ESCO1
Establishment of sister chromatid cohesion N-acetyltransferase 1.
   
  
 0.778
ESCO2
Establishment of sister chromatid cohesion N-acetyltransferase 2.
   
  
 0.741
ASMTL
Acetylserotonin O-methyltransferase like.
  
  
 0.720
SLC1A5
Amino acid transporter.
   
  
 0.714
SLC1A2
Amino acid transporter.
   
  
 0.684
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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