STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYGBGlycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)    
Predicted Functional Partners:
PGM1
Phosphoglucomutase 1; Belongs to the phosphohexose mutase family.
  
 
 0.997
AGL
Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase.
  
 0.997
GBE1
1,4-alpha-glucan branching enzyme 1.
  
 0.995
UGP2
UTP--glucose-1-phosphate uridylyltransferase.
   
 
 0.961
PGM2
Phosphoglucomutase 2; Belongs to the phosphohexose mutase family.
  
 
 0.957
PGM2L1
Phosphoglucomutase 2 like 1.
  
 
 0.957
MGAM
Maltase-glucoamylase.
    
 0.931
MGAM2
Maltase-glucoamylase 2 (putative).
    
 0.931
PYGM
Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 
0.916
RIPK3
Receptor interacting serine/threonine kinase 3.
   
 0.913
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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