node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGRP | CCK | ENSOARP00000003192 | ENSOARP00000003534 | Agouti related neuropeptide. | Cholecystokinin. | 0.951 |
AGRP | LEP | ENSOARP00000003192 | ENSOARP00000002554 | Agouti related neuropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.979 |
AGRP | MC4R | ENSOARP00000003192 | ENSOARP00000004310 | Agouti related neuropeptide. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.951 |
AGRP | NPY | ENSOARP00000003192 | ENSOARP00000011701 | Agouti related neuropeptide. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.985 |
AGRP | NPY1R | ENSOARP00000003192 | ENSOARP00000014658 | Agouti related neuropeptide. | Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.760 |
AGRP | NPY2R | ENSOARP00000003192 | ENSOARP00000016097 | Agouti related neuropeptide. | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.596 |
AGRP | NPY5R | ENSOARP00000003192 | ENSOARP00000000216 | Agouti related neuropeptide. | Neuropeptide Y receptor Y5. | 0.517 |
AGRP | POMC | ENSOARP00000003192 | ENSOARP00000019583 | Agouti related neuropeptide. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. | 0.985 |
AGRP | PYY-2 | ENSOARP00000003192 | ENSOARP00000006899 | Agouti related neuropeptide. | Uncharacterized protein. | 0.832 |
CCK | AGRP | ENSOARP00000003534 | ENSOARP00000003192 | Cholecystokinin. | Agouti related neuropeptide. | 0.951 |
CCK | LEP | ENSOARP00000003534 | ENSOARP00000002554 | Cholecystokinin. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.856 |
CCK | MC4R | ENSOARP00000003534 | ENSOARP00000004310 | Cholecystokinin. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.861 |
CCK | NPY | ENSOARP00000003534 | ENSOARP00000011701 | Cholecystokinin. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.973 |
CCK | NPY2R | ENSOARP00000003534 | ENSOARP00000016097 | Cholecystokinin. | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.480 |
CCK | POMC | ENSOARP00000003534 | ENSOARP00000019583 | Cholecystokinin. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. | 0.896 |
CCK | PYY-2 | ENSOARP00000003534 | ENSOARP00000006899 | Cholecystokinin. | Uncharacterized protein. | 0.945 |
LEP | AGRP | ENSOARP00000002554 | ENSOARP00000003192 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Agouti related neuropeptide. | 0.979 |
LEP | CCK | ENSOARP00000002554 | ENSOARP00000003534 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Cholecystokinin. | 0.856 |
LEP | MC4R | ENSOARP00000002554 | ENSOARP00000004310 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.874 |
LEP | NPY | ENSOARP00000002554 | ENSOARP00000011701 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.984 |