STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YWHAE14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (235 aa)    
Predicted Functional Partners:
CDC25C
Cell division cycle 25C
   
 0.940
CDC25B
Cell division cycle 25B
   
 0.885
FOXO3
Forkhead box protein O3
    
 0.883
BAD
BCL2-associated agonist of cell death
    
  0.869
WWTR1
WW domain containing transcription regulator 1
   
 0.848
NGFRAP1
Brain expressed X-linked 3; Nerve growth factor receptor (TNFRSF16) associated protein 1
   
 0.830
ENSOARG00000000275
Uncharacterized protein; Belongs to the 14-3-3 family
     
 
0.800
YWHAB
14-3-3 protein beta/alpha ; Belongs to the 14-3-3 family
   
 
0.795
CDC25A
Cell division cycle 25A
   
 
 0.792
YWHAG
14-3-3 protein gamma; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma; Belongs to the 14-3-3 family
   
 
0.752
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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