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GJA8 protein (Ovis aries) - STRING interaction network
"GJA8" - Gap junction alpha-8 protein in Ovis aries
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GJA8Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily (440 aa)    
Predicted Functional Partners:
CRYAA
Uncharacterized protein; Alpha-crystallin A chain ; Belongs to the small heat shock protein (HSP20) family (198 aa)
     
   
  0.820
CRYBA1
Crystallin, beta A1; Belongs to the beta/gamma-crystallin family (215 aa)
     
   
  0.814
CRYBB1
Crystallin, beta B1; Belongs to the beta/gamma-crystallin family (254 aa)
     
   
  0.804
CRYBB2
Crystallin, beta B2; Belongs to the beta/gamma-crystallin family (205 aa)
     
   
  0.802
CRYGB
Crystallin, gamma B; Belongs to the beta/gamma-crystallin family (175 aa)
     
   
  0.772
NT5C1A
5’-nucleotidase, cytosolic IA (368 aa)
           
  0.739
BFSP2
Beaded filament structural protein 2, phakinin; Belongs to the intermediate filament family (423 aa)
     
   
  0.729
PHAX
Phosphorylated adaptor for RNA export (394 aa)
           
  0.723
MIP
Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core; Belongs to the MIP/aquaporin (TC 1.A.8) family (263 aa)
     
 
  0.722
BFSP1
Beaded filament structural protein 1, filensin (663 aa)
     
   
  0.702
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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