STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GJA8Gap junction alpha-8 protein; Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore; Belongs to the connexin family. Alpha-type (group II) subfamily. (440 aa)    
Predicted Functional Partners:
BFSP1
Beaded filament structural protein 1; Belongs to the intermediate filament family.
      
 0.878
CRYBB2
Crystallin beta B2; Belongs to the beta/gamma-crystallin family.
      
 0.868
GJB2
Gap junction beta-2 protein; Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).
  
 
0.845
BFSP2
Beaded filament structural protein 2; Belongs to the intermediate filament family.
      
 0.828
CWF19L2
CWF19 like cell cycle control factor 2.
      
 0.818
CRYAA
Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
   
  
 0.799
CRYGA
Crystallin gamma A; Belongs to the beta/gamma-crystallin family.
      
 0.767
CRYBB1
Crystallin beta B1; Belongs to the beta/gamma-crystallin family.
   
  
 0.733
OTOP2
Otopetrin 2.
      
 0.721
PITX3
Homeobox protein.
      
 0.721
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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