STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIT1Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3' (324 aa)    
Predicted Functional Partners:
LHX4
LIM homeobox 4
   
 
 0.883
PROP1
Ovis aries PROP paired-like homeobox 1 (PROP1), mRNA
   
 
 0.877
LHX3
LIM homeobox 3
   
 
 0.858
TSHB
Thyroid stimulating hormone, beta
   
  
 0.848
GHRHR
Uncharacterized protein; Ovis aries growth hormone releasing hormone receptor (GHRHR), mRNA
   
  
 0.844
TBX19
T-box 19
   
  
 0.843
CGA
Ovis aries glycoprotein hormones, alpha polypeptide (CGA), mRNA; Belongs to the glycoprotein hormones subunit alpha family
   
  
 0.838
ARL11
ADP-ribosylation factor-like 11; Belongs to the small GTPase superfamily. Arf family
    
 
 0.802
IL17RD
Interleukin 17 receptor D
      
 0.790
HIF1AN
Hypoxia inducible factor 1, alpha subunit inhibitor
      
 0.772
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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