STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COL2A1Collagen type II alpha 1 chain. (1490 aa)    
Predicted Functional Partners:
CD44
CD44 molecule (Indian blood group).
    
 0.952
SOX9
SRY-box transcription factor 9.
    
 
 0.922
COL11A1
Collagen type XI alpha 1 chain.
  
0.912
GP6
Uncharacterized protein.
     
 0.909
MMP13
ZnMc domain-containing protein.
   
 0.904
COL11A2
Collagen type XI alpha 2 chain.
  
0.863
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5.
   
 0.852
RUNX2
Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
     
 0.826
COL5A1
Collagen type V alpha 1 chain.
  
0.813
COL5A3
Collagen type V alpha 3 chain.
  
0.812
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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