node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSN3 | SLC11A1 | ENSOARP00000011880 | ENSOARP00000020985 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | 0.539 |
IL1RN | S100A12 | ENSOARP00000022386 | ENSOARP00000000430 | Interleukin-1. | Protein S100; Belongs to the S-100 family. | 0.479 |
IL1RN | SLC11A1 | ENSOARP00000022386 | ENSOARP00000020985 | Interleukin-1. | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | 0.697 |
IL1RN | TLR2 | ENSOARP00000022386 | ENSOARP00000016139 | Interleukin-1. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.537 |
IL1RN | TLR4 | ENSOARP00000022386 | ENSOARP00000006210 | Interleukin-1. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.656 |
NOD2 | SLC11A1 | ENSOARP00000018720 | ENSOARP00000020985 | Nucleotide binding oligomerization domain containing 2. | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | 0.614 |
NOD2 | TLR2 | ENSOARP00000018720 | ENSOARP00000016139 | Nucleotide binding oligomerization domain containing 2. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.907 |
NOD2 | TLR4 | ENSOARP00000018720 | ENSOARP00000006210 | Nucleotide binding oligomerization domain containing 2. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.814 |
PAF1 | SLC11A1 | ENSOARP00000006487 | ENSOARP00000020985 | PAF1 homolog, Paf1/RNA polymerase II complex component. | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | 0.559 |
S100A12 | IL1RN | ENSOARP00000000430 | ENSOARP00000022386 | Protein S100; Belongs to the S-100 family. | Interleukin-1. | 0.479 |
S100A12 | SLC11A1 | ENSOARP00000000430 | ENSOARP00000020985 | Protein S100; Belongs to the S-100 family. | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | 0.824 |
S100A12 | TLR2 | ENSOARP00000000430 | ENSOARP00000016139 | Protein S100; Belongs to the S-100 family. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.458 |
S100A12 | TLR4 | ENSOARP00000000430 | ENSOARP00000006210 | Protein S100; Belongs to the S-100 family. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.756 |
SLC11A1 | CSN3 | ENSOARP00000020985 | ENSOARP00000011880 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. | 0.539 |
SLC11A1 | IL1RN | ENSOARP00000020985 | ENSOARP00000022386 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | Interleukin-1. | 0.697 |
SLC11A1 | NOD2 | ENSOARP00000020985 | ENSOARP00000018720 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | Nucleotide binding oligomerization domain containing 2. | 0.614 |
SLC11A1 | PAF1 | ENSOARP00000020985 | ENSOARP00000006487 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | PAF1 homolog, Paf1/RNA polymerase II complex component. | 0.559 |
SLC11A1 | S100A12 | ENSOARP00000020985 | ENSOARP00000000430 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | Protein S100; Belongs to the S-100 family. | 0.824 |
SLC11A1 | SP110 | ENSOARP00000020985 | ENSOARP00000022170 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | Uncharacterized protein. | 0.655 |
SLC11A1 | SPI1 | ENSOARP00000020985 | ENSOARP00000007015 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] | Spi-1 proto-oncogene. | 0.557 |