STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACRAcrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family. (416 aa)    
Predicted Functional Partners:
RIC3
RIC3 acetylcholine receptor chaperone.
    
 0.858
TESMIN
Testis expressed metallothionein like protein.
      
 0.855
TNP1
Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
   
  
 0.822
ACD
ACD shelterin complex subunit and telomerase recruitment factor.
      
 0.763
CRISP1
Cysteine rich secretory protein 1; Belongs to the CRISP family.
   
 0.729
BOLL
Boule homolog, RNA binding protein.
      
 0.726
ZAN
Zonadhesin (gene/pseudogene).
     
 0.700
PIWIL2
Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family.
      
 0.696
CREM
cAMP responsive element modulator.
      
 0.690
IZUMO1
Izumo-Ig domain-containing protein.
     
 0.676
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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