STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LYZLysozyme C, kidney isozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. (148 aa)    
Predicted Functional Partners:
LTF
Uncharacterized protein; Belongs to the transferrin family.
   
 0.736
W5P942_SHEEP
Beta defensin OBD109a.
      
 0.654
LYG2
Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family.
      
 0.512
W5NUJ7_SHEEP
A2M_recep domain-containing protein.
   
 0.506
W5NXJ3_SHEEP
TED_complement domain-containing protein.
   
 0.506
SLC11A1
Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...]
   
  
 0.496
PRD-SPRRII
Uncharacterized protein.
      
 0.487
MGAM2
Maltase-glucoamylase 2 (putative).
      
 0.455
W5NRI1_SHEEP
A2M_N_2 domain-containing protein.
   
 0.434
S100A12
Protein S100; Belongs to the S-100 family.
   
 0.431
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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