STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SORDSorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By simil [...] (358 aa)    
Predicted Functional Partners:
AKR1B1
Aldo_ket_red domain-containing protein.
  
 0.962
W5P5W4_SHEEP
Uncharacterized protein.
   
 
 0.957
XYLB
Xylulokinase.
  
 
 0.937
HKDC1
Hexokinase domain containing 1.
   
 
 0.935
HK1
Hexokinase 1.
   
 
 0.935
DCXR
Uncharacterized protein.
   
 
 0.926
HK2
Hexokinase 2.
   
 
 0.924
HK3
Hexokinase 3.
   
 
 0.923
ADHFE1
Fe-ADH domain-containing protein.
  
 
 0.892
TKFC
Triokinase and FMN cyclase.
  
 0.890
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: medium (56%) [HD]