node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG14 | CALM2 | ENSOCUP00000033076 | ENSOCUP00000048696 | Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | Uncharacterized protein; Belongs to the calmodulin family. | 0.946 |
ALG14 | IQGAP1 | ENSOCUP00000033076 | ENSOCUP00000026340 | Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | IQ motif containing GTPase activating protein 1. | 0.713 |
CALM2 | ALG14 | ENSOCUP00000048696 | ENSOCUP00000033076 | Uncharacterized protein; Belongs to the calmodulin family. | Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | 0.946 |
CALM2 | CAV3 | ENSOCUP00000048696 | ENSOCUP00000022576 | Uncharacterized protein; Belongs to the calmodulin family. | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | 0.872 |
CALM2 | FKBP1B | ENSOCUP00000048696 | ENSOCUP00000009643 | Uncharacterized protein; Belongs to the calmodulin family. | Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). | 0.966 |
CALM2 | IQGAP1 | ENSOCUP00000048696 | ENSOCUP00000026340 | Uncharacterized protein; Belongs to the calmodulin family. | IQ motif containing GTPase activating protein 1. | 0.957 |
CALM2 | PPP3CA | ENSOCUP00000048696 | ENSOCUP00000045121 | Uncharacterized protein; Belongs to the calmodulin family. | Serine/threonine-protein phosphatase. | 0.903 |
CALM2 | PRKACB | ENSOCUP00000048696 | ENSOCUP00000043583 | Uncharacterized protein; Belongs to the calmodulin family. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.952 |
CALM2 | RYR1 | ENSOCUP00000048696 | ENSOCUP00000025335 | Uncharacterized protein; Belongs to the calmodulin family. | Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] | 0.916 |
CALM2 | RYR2 | ENSOCUP00000048696 | ENSOCUP00000002126 | Uncharacterized protein; Belongs to the calmodulin family. | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] | 0.974 |
CALM2 | TRDN | ENSOCUP00000048696 | ENSOCUP00000024583 | Uncharacterized protein; Belongs to the calmodulin family. | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). | 0.899 |
CALM2 | TRPV1 | ENSOCUP00000048696 | ENSOCUP00000010529 | Uncharacterized protein; Belongs to the calmodulin family. | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Ac [...] | 0.910 |
CAV3 | CALM2 | ENSOCUP00000022576 | ENSOCUP00000048696 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Uncharacterized protein; Belongs to the calmodulin family. | 0.872 |
CAV3 | PRKACB | ENSOCUP00000022576 | ENSOCUP00000043583 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.601 |
CAV3 | RYR1 | ENSOCUP00000022576 | ENSOCUP00000025335 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] | 0.656 |
CAV3 | RYR2 | ENSOCUP00000022576 | ENSOCUP00000002126 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] | 0.679 |
CAV3 | TRDN | ENSOCUP00000022576 | ENSOCUP00000024583 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). | 0.549 |
FKBP1B | CALM2 | ENSOCUP00000009643 | ENSOCUP00000048696 | Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). | Uncharacterized protein; Belongs to the calmodulin family. | 0.966 |
FKBP1B | PPP3CA | ENSOCUP00000009643 | ENSOCUP00000045121 | Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). | Serine/threonine-protein phosphatase. | 0.687 |
FKBP1B | PRKACB | ENSOCUP00000009643 | ENSOCUP00000043583 | Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.726 |