node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP2 | CLCNKA | ENSOCUP00000047709 | ENSOCUP00000035339 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | 0.619 |
AQP2 | KCNJ1 | ENSOCUP00000047709 | ENSOCUP00000011546 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Potassium voltage-gated channel subfamily J member 1. | 0.458 |
AQP2 | SLC12A1 | ENSOCUP00000047709 | ENSOCUP00000014189 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Belongs to the SLC12A transporter family. | 0.872 |
AQP2 | SLC12A3 | ENSOCUP00000047709 | ENSOCUP00000034255 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Uncharacterized protein. | 0.704 |
BSND | CLCNKA | ENSOCUP00000003918 | ENSOCUP00000035339 | Uncharacterized protein. | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | 0.931 |
BSND | KCNJ1 | ENSOCUP00000003918 | ENSOCUP00000011546 | Uncharacterized protein. | Potassium voltage-gated channel subfamily J member 1. | 0.774 |
BSND | SLC12A1 | ENSOCUP00000003918 | ENSOCUP00000014189 | Uncharacterized protein. | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Belongs to the SLC12A transporter family. | 0.784 |
BSND | SLC12A3 | ENSOCUP00000003918 | ENSOCUP00000034255 | Uncharacterized protein. | Uncharacterized protein. | 0.735 |
CLCNKA | AQP2 | ENSOCUP00000035339 | ENSOCUP00000047709 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.619 |
CLCNKA | BSND | ENSOCUP00000035339 | ENSOCUP00000003918 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Uncharacterized protein. | 0.931 |
CLCNKA | CLDN16 | ENSOCUP00000035339 | ENSOCUP00000009865 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.551 |
CLCNKA | KCNH8 | ENSOCUP00000035339 | ENSOCUP00000014056 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Potassium voltage-gated channel subfamily H member 8. | 0.563 |
CLCNKA | KCNJ1 | ENSOCUP00000035339 | ENSOCUP00000011546 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Potassium voltage-gated channel subfamily J member 1. | 0.626 |
CLCNKA | OSTM1 | ENSOCUP00000035339 | ENSOCUP00000013815 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Uncharacterized protein. | 0.736 |
CLCNKA | SLC12A1 | ENSOCUP00000035339 | ENSOCUP00000014189 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Belongs to the SLC12A transporter family. | 0.796 |
CLCNKA | SLC12A3 | ENSOCUP00000035339 | ENSOCUP00000034255 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Uncharacterized protein. | 0.746 |
CLCNKA | TMC5 | ENSOCUP00000035339 | ENSOCUP00000003112 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Transmembrane channel-like protein. | 0.593 |
CLCNKA | TMEM82 | ENSOCUP00000035339 | ENSOCUP00000003963 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | Transmembrane protein 82. | 0.680 |
CLDN16 | CLCNKA | ENSOCUP00000009865 | ENSOCUP00000035339 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. | 0.551 |
CLDN16 | KCNJ1 | ENSOCUP00000009865 | ENSOCUP00000011546 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Potassium voltage-gated channel subfamily J member 1. | 0.548 |